Award Data

PROJECT SUMMARY The research project outlined in this Fast track SBIR submission will develop the RAE cHealth platform into a tool to address digital inequities and support peer-based collaborative recovery for individuals with substance use disorder. In this proposal, the investigators intend to develop and deploy the RAE cHealth system- consisting of a wearable sensor and a smartphone app. RAE c ...

Project Summary/Abstract Maternal use and addiction to opioids has resulted in an unprecedented rise in drug withdrawal complications in newborns, known as neonatal opioid withdrawal syndrome (NOWS), also referred to as neonatal abstinence syndrome (NAS). Between 2004 and 2016, NOWS admissions increased more than fourfold, with an average hospital stay nearly 3.2 times longer (15.9 hospital days c ...

PROJECT SUMMARY The research project outlined in this SBIR submission will develop the Realize, Analyze, Engage (RAE) platform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorder. In this proposal, the investigators intend to deploy the RAE system- consisting of a wearable sensor, a smartphone app, and a clinical portal- to provide individuals in ...

Currently available anti-thymocyte globulin (ATG) products are polyclonal animal antibodies (ATGAM – equine polyclonal ATG, Thymoglobulin – rabbit polyclonal ATG) and have found broad use as immune tolerizing agents, particularly for induction therapy in a majority of tissue transplants, for acute transplant rejection, and as treatment for graft vs. host disease following bone marrow transplan ...

Abstract There is an urgent need for new diagnostic approaches for early identification and progression in Alzheimer s diseaseADand related dementiasADRDNIA s Strategic Direction C and D to improve our understanding and develop interventions for mild cognitive impairmentMCIthe prodrome of ADThis proposal focuses on sleep statusa known hallmark of neurological diseaseand commonly present in MCI ADS ...

PROJECT SUMMARYHeart disease is the leading cause of mortality and morbidity in the worldCoronary heart disease is the most common type of heart disease and results from the blockage of blood vessels that supply blood to the heartA heart attack or myocardial infarctionMIoccurs when loss of blood flow causes the death of oxygenstarved cardiomyocytesIn humansthere is little or no significant cardiac ...

DESCRIPTION provided by applicant A research plan is proposed to produce potent human polyclonal antibodies against influenza viruses by immunizing genetically modified bovines with seasonal influenza vaccine in combination with a strong adjuvant and immune stimulator Previous studies have demonstrated that genetically engineered bovines are capable of producing large amounts of human polyclo ...

PROJECT SUMMARY This Phase II project aims to continue development of a commercial qualityinnovative cloud hosted information management systemcalled Climbthat will increase laboratory efficiency and provide improved capabilities for research laboratoriesClimb is designed to offer integrated laboratory process management modules that include mobile communications tools data monitoring and alert sy ...

DESCRIPTION provided by applicant There are an estimated million Americans with chronic kidney disease CKD Early diagnosis and treatment are the only cost effective means to reverse this growing problem NIH recognizes the challenge to diagnose CKD early during its initiation and development phases in order to prevent further renal damage reduce cardiovascular risk and minimize the econ ...

DESCRIPTION (provided by applicant): The Centers for Disease Control (CDC) has identified falls-related traumatic brain injury (TBI) in older adults as a significant and unrecognized public health issue; with 8000 deaths from falls- related TBI in older adults and 56,000 hospitalizations, at a mean cost of 16,006/ 19,191 for women/men gt64 years reported in 2005; prompting a public service campai ...