Award Data

The objective of the proposed program is the development of a mobile and non-invasive cerebro-physiological monitor that will permit the tracking of cerebral functions and the identification of developing pathologic brain conditions in wounded soldiers during transport and under medical care in forward areas. Specifically, the purpose of the system will be to continuously track cerebral blood flow ...

The problem of inaccurate patient identification due to errors introduced during data capture or due to syntactic and semantic differences between patient registration systems is one of the biggest challenges facing healthcare today. An inefficient and inaccurate master patient index introduces duplicate and/or overlaid patient records which can then cause inappropriate or delayed treatments, adve ...

Phase I studies demonstrate that human adipose stem cells (ASCs) exhibit characteristics of chondrocytes when cultured in chondrogenic media (CM) and this is enhanced when they are first encapsulated in low viscosity, high mannuronate content alginate beads that are less than 200fYm in diameter containing 250 cells/bead. The microencapsulated cells express mRNAs for factors associated with chondr ...

The proposed Phase II program is designed to build upon the successes of the Phase I feasibility study and develop an advanced blood simulant for training of combat first responders in the use of modern hemostatic products. The blood simulant will exhibit a caking/clotting response in the presence of simulated hemostatic agents while accurately approximating the viscosity and color of human blood ...

Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical attention for complex skin defects, with 50,000 people hospitalized for burns and 13,000 requiring sk ...

Limb loss affects approximately 1.9 million people in the United States. It is well established that lower-limb amputees show greater metabolic demands during gait and more limited mobility compared to non-disabled individuals. Currently, there is no lower-extremity prosthesis available that can monitor the metabolic costs of the amputee. The proposed solution, code-named TEQUILA (Total Energy exp ...

In this project, Parabon NanoLabs will employ its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce artificial vaccines against the biothreat agent ricin on DNA origami decorated first with natural epitopes and ultimately with artificial epitotopes (hereafter"mimotope") constructed from a predefined set of ...

The Army Defense Health Program has a need for a novel freestanding device to sample and collect a broad spectrum of flying insects (order Diptera) for the purpose of analyzing possible disease vectors. The sampling device is required to be effective against mosquitoes (Anopheles, Aedes, and Culex) and sand flies (Phlebotomus and Lutzomyai) in particular, and with desired applicability to other sp ...

Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical attention for complex skin defects, with 50,000 people hospitalized for burns and 13,000 requiring sk ...

Traumatic injuries to the head and neck region comprise as much as 30 percent of all combat injuries observed today. These injuries often involve multiple tissues including dermal, muscle, cartilage and bone. This work aims to address this critical need by treating a composite tissue injury model in the ear. We will use an alginate microbead cell delivery system