Award Data

Drug metabolism problems such as production of toxic metabolites and unfavorable pharmacokinetics cause almost half of all drug candidate failures during clinical trials. Although glucuronidation is one of the most important routes of drug metabolism, the broad and overlapping substrate specificity of the hepatic UDP-glucuronosyltransferases (UGTs) that catalyze glucuronidation remains poorly unde ...

The overall goal of the proposed program is to demonstrate the technical and scientific feasibility of combining the biopulping and fiber loading technologies at a pilot-scale simulating industrial conditions to minimize the initial research and development costs. The combined technology will save electrical energy, improve paper quality (strength and optical properties), and reduce the environmen ...

DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

DESCRIPTION (provided by applicant): This application proposes to develop two interactive voice response (IVR) products: Alzheimer's Early Recognition Telephone System (ALERTS) and Telephonic Remote Evaluation of Neuropsychological Deficits (TREND). Research results from a previous Phase I grant provide the conceptual and scientific foundations for these products. Two independent research projec ...

This Small Business Innovation Research Phase II project will develop the Local Electrode Atom Probe (LEAP) to rapidly provide three-dimensional atomic-scale imaging and elemental identification of nano-biotechnology devices. Structural characterization of nano-biotechnology devices is currently problematic because available microscopy and analytical techniques have substantial limitations in quan ...

This Small Business Innovation Research (SBIR) Phase II project will develop a digital video surveillance system prototype. Over the past few years, video surveillance systems have been moving from analog to digital. The success of a digital video surveillance system depends on three key enabling technologies: compression, search and retrieval and network transmission. Existing commercial systems ...

This Small Business Innovation Research Phase II project will develop novel DNA polymerase reagents for use in current and developing DNA diagnostic procedures. The approach is to develop thermophilic phage DNA replicases in place of the currently used DNA repair enzymes. The feasibility of this approach was demonstrated during Phase I research. This follow on Phase II project will extend the meth ...

DESCRIPTION (provided by applicant): The explosion of new molecular laboratory tests has significantly improved diagnosis and management of leukemia, but the problem of a renewable supply of stable controls for test validation has not been resolved. The current paradigm of using cell lines or patient specimens for quality assurance is unsatisfactory because materials are unstable, potentially inf ...

DESCRIPTION (provided by applicant): This Phase II project develops a novel, comprehensive set of control products for quality assurance of molecular-based cystic fibrosis (OF) diagnostic tests. Controls are tested alongside patient specimens, as required by Federal regulations, to ensure quality in medical testing. Adoption of molecular diagnostics technology is inhibited by lack of commercial qu ...

An emerging hybrid between the classical viral and non-viral gene delivery fields: synthetic virus-like vectors have gained ground. These condensed DNA particles carry one or more virus-like characteristics that make them more efficient at (a) certain step(s) of delivery, yet maintaining advantages over real viruses. The first goal of these studies is to lay the foundation for the construction of ...