Award Data

This Small Business Innovation Research (SBIR) Phase II project will assess the performance of autonomic-healing concrete asphalt through large-scale testing. Each year, about 500 million tons of hot mix asphalt is produced in America, with an average price of $80 per ton. Compared to concrete, hot mix asphalt features lower material cost, but is prone to fatigue cracking when subject to repeated ...

DESCRIPTION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-psychotics, as well drugs used for neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The relatively recent discovery of a ...

DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as atherosclerosis. Whereas current anti-inflammatory drugs such as NSAIDs target secondary effects that are induced after inflammation is already est ...

More than 52% of U.S. urban highway congestion is a direct result of highway incidents. Federal and State transportation authorities are searching for quick, cost-effective and efficient highway incident detection and warning systems. Several solutions have been proposed but none could satisfy requirements of transportation authorities. Central Signal's research and development, grounded in mor ...

The proposed study aims at accelerated development of Mo-Si-B-X (X=Ti, Zr, Hf, Re, Mn) alloys with an optimized balance of properties, via an approach of integrating thermodynamic modeling with experimental study.   On the basis of the Mo-Si-B-X (X=Ti, Zr, Hf) database developed in Phase I, a thermodynamic database of the Mo-Si-B-O-X (X=Ti, Zr, Hf, Re, Mn) system will be developed using the Calp ...

In Phase I, technical and commercial feasibilty has been demonstrated for low force FSW processes that could be implemented onto a flexible and portable robotic system. The processes were implemented on a standard industrial robot, which could be integrated into a portable FSW system for fabrication of aluminum modules for ship superstructure. Two approaches were demonstrated, including a low forc ...

DESCRIPTION (provided by applicant): Cryptosporidiosis is a leading cause of diarrheal disease worldwide and is a category B biothreat agent. Two major species, Cryptosporidium hominis and Cryptosporidium parvum are responsible for over ninety percent of cases in man. C. parvum is zoonotic, with a reservoir in cattle, where it is an economically important cause of disease. There is currently no sp ...

DESCRIPTION (provided by applicant): The long term objective of this research is to develop improved DNA polymerases that will substantially advance Sanger and next generation sequencing technologies. The primary goal of the Phase I research was to develop a rapid and inexpensive method to perform Sanger sequencing directly from single bacterial colonies. This method bypasses the time and expen ...

DESCRIPTION (provided by applicant): A hernia occurs when part of an internal organ bulges through a weak area of fascia, with most hernias occurring in the abdomen. Surgical hernia repair is one of the most commonly performed surgeries in the US. While using prosthetic mesh as a reinforcement has significantly improved surgical outcomes, the rate of hernia recurrence can be more than 50%. Current ...

The severity of the lunar dust problems encountered during the Apollo missions were consistently underestimated by ground tests, illustrating the need to develop significantly better lunar dust simulants and simulation facilities. ORBITEC is proposing to continue developing high-fidelity lunar dust simulants that better match the unique properties of lunar dust than existing regolith simulants (s ...