Award Data

DESCRIPTION (provided by applicant): The overall goal of this proposal is to create a robust one pot, in vitro, multi-gram scale synthesis of activated sugars for drug discovery and biochemical research purposes. Natural product glycosylation is vital for the discovery of new pharmaceutical compounds. While it has been recognized for some time that many biologically active natural products owe muc ...

Many DOD systems require high-performance digital signal processing and image processing functions that cannot be implemented efficiently on conventional microprocessors. Systems engineers often address these issues by mapping the compute-intensive portions of these applications onto FPGAs in the form of hardware accelerators, as part of a hardware-software co-design. However, a manual hardware im ...

Our goal is a wearable device-and-algorithm platform for real-time predictive assessment of health status, namely progression of hypovolemia and onset-risk of cardiovascular collapse, to facilitate improved triage of combat-related trauma. This involves

The early recognition of severe hemorrhage is a key factor towards reducing mortality and morbidity from battlefield insults. Although near-infrared (NIR) instruments have shown promise in recognizing hemorrhage, specific confounding factors must be solved to be reliable in early hemorrhage shock detection. Our hypothesis is that confounding factors can be reduced or eliminated by i) using incre ...

Rotorcraft are increasingly turning toward high-resolution Ka- through W-band radar sensors that can image terrain and obstructions but also see through the particulates that confound infrared and optical sensors, such as sand, ocean spray, and fog. As with any onboard sensor, designers must consider the antenna/platform interaction, and mature tools exist to address this type of problem. However, ...

DESCRIPTION (provided by applicant): Coramed is designing a next-generation point-of-care (POC) instrument, the TEG 6500, for monitoring patient hemostasis on demand. The instrument will introduce a completely new technology for monitoring clot formation and breakdown that is well suited for the continuum of settings from inside the hospital, to ambulatory care clinics, physician offices, and pati ...

NASA calculation that over a kg of packaging waste are generated per day for a 6 member crew. This represents over 1.5 metric tons of waste during a Mars mission. Currently, these wastes are considered a disposal burden. However, packaging can designed to have valuable secondary uses which can lighten other payloads. These include: Light generation, electricity generation, storage structures, ...

We will develop an efficient tool for formal verification of PowerPC 750 executables. The PowerPC 750 architecture is used in the radiation-hardened RAD750 flight-control computers that are utilized in many space missions. The resulting tool will be capable of formally checking: 1) the equivalence of two instruction sequences; and 2) properties of a given instruction sequence. The tool will automa ...

DESCRIPTION (provided by applicant): There currently is a real need for a long term and objective alcohol biomarker to both monitor alcohol-impaired healthcare professionals, and to aid in the selection of organ transplant recipients, particularly liver transplant recipients. We recently concluded a Phase I study that compared the presence of the direct alcohol biomarker ethyl glucuronide (EtG) in ...

High sensitivity HgCdTe focal plane arrays operating at 77 K can be tailored for response across the infrared spectrum. However, the cooling systems required to achieve the desired sensitivity makes them heavy and therefore unsuitable for the next generation of interceptor seekers. Reducing cooling requirements will allow the detector’s integration in lighter and more compact systems. Superior o ...