Award Data

DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

In composites, not only can properties vary with load direction, fiber based composites also offer the unique ability to tailor material properties locally. Localized matrix or fiber architecture changes can meet local mechanical, electrical, or thermal loads within a component or vehicle, without weight penalty or resort to additional external structures. In Phase I, the team used 3TEX 3-D wea ...

Strength and durability of commonly used bonded and bolted composite-to-composite and composite-to-metal structural joints suffer from sharp geometry variations, mismatch of elastic moduli, Poisson’s ratios, coefficients of thermal expansion and thermal conductivity of the adherends, altogether causing high stress concentration and premature joint failure. The proposed work is focused on develop ...

DESCRIPTION (provided by applicant): Many contemporary medical and dental therapies include the replacement or repair of tissues using materials such as metal. Currently there are at least 150,000 hip replacements, 300,000 knee replacements, and 500,000 dental implant procedures performed in the US each year (Kurtz, Mowat et al. 2005). These numbers are expected to increase as the baby boom gen ...

DESCRIPTION (provided by applicant): Bridging the gap between science and practice continues as a major problem in the effective delivery of treatments for alcohol abuse and dependence. Twelve Step Facilitation, an empirically supported therapy, is well positioned to bridge this gap. That is, although TSF is a highly structured manual driven approach, its basic tenets are familiar to many counselo ...

Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, there presently are no effective therapies to control excess mucus secretion in these diseases, and very few potential therapeutic targets. We discovered that a ...

DESCRIPTION (provided by applicant): This Phase II Small Business Innovative Research application proposes to dramatically expand the commercial availability of optical coherence tomography (OCT) technology for pre-clinical human and animal research applications by commercializing Fourier-domain OCT (FD-OCT) technology and developing robust interfaces for retinal OCT imaging in a wide variety of s ...

DESCRIPTION (provided by applicant): The objective of this SBIR Phase II project is to develop a novel fluorescence detection technology for highly parallel microarray analysis that will provide dramatically increased fluorescence signals so that high-sensitivity detection can be achieved with an inexpensive CCD camera and low-cost disposable plastic chips. The technology is based on the phenomeno ...

DESCRIPTION (provided by applicant): Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis and its product, malonyl-CoA, inhibits fatty acid oxidation. These functions make ACC a prime target for the development of therapeutics to treat obesity and type 2 diabetes. Knockout studies in mice, and animal studies with ACC inhibitors, have validated this approach. The most po ...