Award Data

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DESCRIPTION (provided by applicant): Serious wheelchair accidents have risen to almost 37,000 per year. Users of power chairs are three times as likely to have accidents as users of manual chairs! Many people can neither walk nor successfully navigate a wheelchair, e.g., many with MS, quadraplegia, spinal stenosis, visual and other impairments. The Safety Sensing Independence-Enhancing Wheelch ...

DESCRIPTION (provided by applicant): ActivX Biosciences (ActivX) will develop and validate a novel toxicoproteomics platform to correlate changes in protein activity with compound toxicology. This platform uses fluorescent chemical probes to interrogate catalytically active proteins related by super-family derived from any biological sample. Alterations in protein activity are expected to be mor ...

DESCRIPTION (Applicant's abstract): The proposed research evaluates the efficacy of the Alertness Profiling (AP) System as a method for objectively quantifying alertness in Sleep Apnea (SA) patients. The AP simultaneously measures electroencephalographic (EEG) indices and performance during vigilance, attention and memory tests. Combining EED and neurobehavioral assessment in a one-hour session, t ...

DESCRIPTION (provided by applicant): Galactosemia is a potentially lethal, but preventable, disease of newborns. In Phase I of this grant, we demonstrated that a 13C-galactose breath test could be used to assess the degree of impairment of whole body galactose oxidation in more than 90 galactosemic children with a broad spectrum of mutations in the human GALT gene that codes for galactose-l-phosph ...

DESCRIPTION (provided by applicant): Scientists have documented the phenomenon of fetal ceils in maternal blood, and envisioned using them for noninvasive prenatal screening. A key limiting factor is the small number of fetal cells in the maternal circulation, making fetal cell isolation difficult and limiting the accuracy of genetic analysis. Current emphasis is on simple, practical and reprod ...

DESCRIPTION (provided by applicant): Automated karyotyping is an important procedure in cytogenetics labs worldwide. Multiplex fluorescence in situ hybridization (M-FISH) is a relatively recent development that uses multicolor chromosome painting probes and multispectral image analysis to identify subtle and complex chromosomal rearrangements. It promises to make automated karyotyping faster, m ...

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DESCRIPTION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a self-discovering wireless connectivity network for medical devices used in the home. Devices utilizing this network will automatically communicate with a home patient-management Internet appliance using a self-discovering wireless link. A self-discovering wireless network is a communication ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a flexible infrared microbolometer based endoscope for use during surgical heat treatments to accurately measure tissue temperatures. The primary phase II goal is to create the smallest far-infrared camera ever developed to provide real-time spatially accurate two-dimensional surface temperature measurem ...