Award Data

Under the parent grantTetra Discovery Partners is developing phosphodiesteraseBPDE Ballosteric inhibitors as a treatment for major depressive disorderUniquelythe Tetra drug will address inflammation as a contributor to depressionThis is a new mechanism of action for an antidepressant drug which should prove complimentary to current therapeuticsThe company estimates thatof patients with depression ...

This Phase II development program will utilize a novel new 3D printing process to produce multifunction aluminum parts with integrated health monitoring sensors. In particular, Ultrasonic Additive Manufacturing will be used to embed optical fiber strain sensors anywhere in a metal part that can subsequently be used for structural health monitoring (SHM). Success in this program enables real time s ...

This Phase II development program will utilize a novel new 3D printing process to produce high performance heat exchangers embedded in CubeSat structures with integrated temperature monitoring sensors. The embedded heat exchanger is part of a multifunctional three dimensional CubeSat structure that will simultaneously accommodate thermal and mechanical loads, and offer radiation protection via mul ...

The goal of this Phase II SBIR program is to demonstrate the application of Ultrasonic Additive Manufacturing (UAM) solid state metal 3D printing to create new and innovative of metal matrix composites for selective reinforcement and lightweighting. Our intent is to enable Space Launch System structures with superior mechanical properties and increased reliability, and validate these advancements ...

Access to experienced technicians is not always available to a maintainer at sea. Correcting naval electronic systems issues as they occur can leverage accumulated knowledge that resides in databases, detailed test plans, repair procedures, and other documents if available to ship-based maintainers. This effort is to develop an Interactive Instructor chatbot technology that is an interface between ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be an improved cybersecurity posture among industries that rely on mission-critical computing systems that are difficult to patch and/or monitor. Many technical failures on these systems, including information breaches, equipment malfunctions, and malware infestations, stem from longstan ...

Versatile construction materials are under development where readily available raw materials (soils) and indigenous construction materials are blended to produce high-performance hydraulic cements. Abundant natural fabrics are used as reinforcement to produce indigenous ferrocements. Natural foaming agents are also used to produce indigenous aerated concrete. Sandwich composites comprising indigen ...

Fatigue properties of metallic aerospace structures are improved significantly by cold working to impart favorable compressive residual stresses (RS) at and near the surface. In Phases I and II, Proto designed and developed a first generation x-ray diffraction (XRD) based NDI/E tool to measure RS distributions surrounding cold-worked holes in aerospace structures. Subsequently, Proto self-funded a ...

Accessing a freight locomotive is one of the most basic, daily tasks performed by a railroad engineer. However, this task has historically been difficult due to several factors such as the first step which may be 19 inches above the top of the rail, weather conditions which may make the steps slippery, and the fact that the ground surrounding the locomotive may be uneven or covered in debris or ba ...

DESCRIPTIONprovided by applicantRecent studies have demonstrated the effectiveness of hand held ultrasound imaging in detecting breast cancerparticularly for women with dense breastsThe latest reports have shown the potential to screen for small breast masses otherwise missed by mammography with up toextra cancers detected perscreensA striking aspect of the added detections is that they are predom ...