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THIS PROPOSAL DEALS WITH THE DEVELOPMENT OF A NOVEL THERMOGRAPHIC CANCER DETECTION SYSTEM FOR HOME USE. THE BASIC UNDERLYING PRINCIPLE DEALS WITH MICROCAPSULES OF TEMPERATURE SENSITIVE LIQUID CRYSTALLINE MATERIALS IN POLYMERIC SHELLS AS A FREE FLOWING POWDER. THESE CAPSULES, WHEN APPLIED TO THE SKIN OF SUSPECTED PATIENTS, WILL PROVIDE A VISUAL THERMOGRAPHIC SCAN TO DETECT UNUSUAL ABNORMAL SKIN TEM ...

THE APPLICATION OF A IN VITRO MODEL SYSTEM FOR THE ISOLATION AND PROPAGATION OF CELLS HAVING SPECIFIC TUMOR PROPERTIES WILL BE DEMONSTRATED. THE MODEL SYSTEM WILL ALSO BE UTILIZED TO TEST DIFFERENT MEDIA FORMULATIONS AS TO GENERAL APPLICABILITY FOR GROWING CARCINOMA CELLS IN VITRO. DURING PHASE I MONOCLONAL ANTIBODIES ALREADY DEVELOPED AGAINST SERIAL CELL LINES OF HUMAN PROSTATIC CARCINOMA CELLS W ...

THE OBJECTIVE OF THIS SBIR IS TO DEVELOP MONOCLONAL ANTIBODIES SPECIFIC FOR PROSTATE CARCINOMA ANTIGENS. THESE ANTIBODIES WOULD BE DEVELOPED IN PHASE III: 1.) AS A SCREENING TEST FOR EARLY DIAGNOSIS OF PROSTATE CANCER BY IDENTIFYING PROSTATE TUMOR ANTIGENS SHED INTO THE SERUM, 2.) IN IMAGING AND THERAPY OF METASTATIC PROSTATE TUMORS AND 3.) IN IDENTIFYING MALIGNANT CELLS IN BIOPSY SPECIMENS AS PRO ...

THE SPECIFIC AIMS OF THIS PROJECT ARE TWOFOLD. A HAT-SENSITIVE, NON-IMMUNOGLOBULIN SECRETING HUMAN MYELOMA CELL LINE WILL BE DEVELOPED AND CHARACTERIZED FOR SPECIFIC APPLICATION TO HUMAN HYBRIDOMA PRODUCTION AND A TISSUE CULTURE MEDIUM WILL BE DEVELOPED (NOT REQUIRING CONDITIONED MEDIUM OR FETAL BOVINE SERUM) TO SUPPORT THE GROWTH OF THIS CELL LINE. BOTH ARE RECOMMENDED BY THE NCI'S DIVISION OF CA ...

THE MEASUREMENT OF GLYCOSYLATED HEMOGLOBIN IS PROBABLY THE BEST MEANS OF ASSESSING GLUCOSE CONTROL OVER TIME IN DIABETICS. IT NOW APPEARS THERE IS INVERSE CORRELATION BETWEEN THE CONTROL OF GLUCOSE METABOLISM AND COMPLICATIONS OF THE DISEASE IN THAT WELL CONTROLLED DIABETICS DO MUCH BETTER. THE CURRENTLY AVAILABLE ASSAY SYSTEMS FOR QUANTITATING GLYCOSYLATED HEMOGLOBIN ARE BULKY, TIME CONSUMING AND ...

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THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COST-EFFECTIVE REAL TIME IMAGE PROCESSING SYSTEM FOR TRANSMISSION OF HISTOPATHOLOGIC PICTURES BETWEEN PATHOLOGY LABORATORIES. WE PLAN TO CONFIGURE AN IMAGE PROCESSING SYSTEM WITH OFF-THE-SHELF EQUIPMENT AND AVAILABLE SOFTWARE WHERE POSSIBLE. THERE WILL BE A REQUIREMENT TO DEVELOP SOME SOFTWARE TO MAKE THE SYSTEM OPERATE. A STRATEGY NEEDS TO BE DEVELOPE ...

THE LONG TERM OF OBJECTIVE OF THIS PROPOSED WORK IS TO DEVELOP A PRACTICAL MONITORING SYSTEM WHICH NONINVASIVELY AND CONTINUOUSLY MEASURES EVERY SIGNIFICANT PARAMETER ASSOCIATED WITH THE TRANSPORT OF OXYGEN AND CARBON DIOXIDE. THE SYSTEM WOULD HAVE THE ADDITIONAL FEATURES OF REQUIRING MINIMAL PATIENT CONTACT AND BEING NONINTERFERING TO GAS EXCHANGE OR ANY MONITORED PARAMETERS. THUS, THE SYSTEM WOU ...