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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Pre-computed free energy maps for rapid structure-based ligand design

    SBC: SILCSBIO LLC            Topic: 100

    DESCRIPTION provided by applicant In the proposed study a novel approach which has already generated multiple commercial sales for SilcsBio LLC Site Identification by Ligand Competitive Saturation SILCS will be further developed to address customer requests and concerns around SILCS utility Successful commercial application of computational methods for ligand design require a platform th ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Indwelling biosensor for real-time chemotherapeutic blood level monitoring

    SBC: DIAGNOSTIC BIOCHIPS, INC            Topic: NHLBI

    DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of developing a catheter based indwelling biosensor for the real time continuous monitoring of chemotherapeutic blood levels of lung cancer patients A tool that continuously monitors blood drug levels in real time will enable an unprecedented understanding of an individual patientandapos s distinct ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Manufacturing pathogen inactivated platelet lysate to treat corneal inflammation

    SBC: Cambium Medical Technologies LLC            Topic: N

    DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Optimizing correction of the Huntington's disease mutation by trans-splicing

    SBC: RETROTHERAPY, LLC            Topic: 102

    DESCRIPTION provided by applicant Recent studies by my laboratory and collaborators and by others have demonstrated that RNA trans splicing can correct mutations in many different genes in a wide range of disease model systems including Huntingtonandapos s disease Trans splicing is one of a handful of techniques that can convert the expression of a dominant negative mutation into the normal p ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Targeted Therapeutic Nanogels for Effective Treatment of Multidrug-Resistant Bacteria in Wounds

    SBC: NANODERM SCIENCES, INC.            Topic: DHP15007

    This project will produce an antibacterial nanogel platform to combat multidrug-resistant bacterial infections in wounds. Infections by multidrug-resistant bacteria are increasing at an alarming rate and represents a growing threat to US military medicine and public health. Bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), A. baumannii, P. aeruginosa, E. coli and K. pneumonia ha ...

    SBIR Phase I 2015 Department of DefenseDefense Health Agency
  7. Nanobind Hierarchical Silica Lamella for High Molecular Weight DNA Extraction

    SBC: Circulomics Inc.            Topic: 400

    DESCRIPTION provided by applicant As new genetic analysis methods are developed rising emphasis is being placed on high quality sample preparation and the ability to obtain large quantities of high molecular weight and high purity DNA In DNA sequencing rd generation technologies offer long read lengths up to kb and require high quality isolated DNA In gene therapy and DNA vaccines high ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Role of 3D Weight Progression Software in Weight Counseling to Decrease Weight-related Health Disparities Among Adolescent African-American Females

    SBC: Delta Health and Wellness Consulting, LLC            Topic: 102

    DESCRIPTION provided by applicant Childhood and adolescent obesity is a growing epidemic in the United States especially among minorities Research has repeatedly shown that African American youth are disproportionately affected by the obesity epidemic especially African American girls By almost percent of black girls were obese the highest prevalence of any age group by gender ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Connecting Cultures and Technology: Addressing Disparities in Mental Health Intervention for Refugees

    SBC: GAMETHEORY, INC            Topic: NIMHD

    DESCRIPTION provided by applicant Thousands of individuals seek refuge in the United States to escape atrocities of war and torture in their country of origin An overwhelming majority of these individuals continue to struggle with Chronic Traumatic Stress CTS the persistence of prior traumatic events e g re experiencing past trauma coupled with daily post migration stressors e g pove ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Development and Assessment of Video-Based Directly Observed Therapy for Tuberculosis

    SBC: EMOCHA MOBILE HEALTH INC.            Topic: NIMHD

    DESCRIPTION provided by applicant The Development and Assessment of Video Based Directly Observed Treatment for Tuberculosis TB is a project to develop a patient centered cost saving alternative strategy to ensure TB treatment completion TB disproportionately affects vulnerable populations and there are barriers to TB care `Directly observed therapyandapos DOT is the recommended standa ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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