Award Data

DESCRIPTION (provided by applicant): Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH). Without PAH, the patient with PKU cannot metabolize phenylalanine (PHE) to tyrosine. The resulting accumulation of PHE and the accumulation of phenylpyruvate by a secondary metabolic pathway in the patient's blood produce neuropathies including severe mental retardation, behavior ...

The accurate measurement of blood glucose concentration is important in the management of diabetes. Current methods of glucose monitoring involve piercing the skin and collecting blood samples for analysis up to four times daily or more. Even the non-invasive Glucowatch tm glucose monitoring system requires twice daily blood collection for calibration. This original, innovative invention will decr ...

"This project will develop and implement in embedded hardware the capability needed to configure pre hit, a component level automation infrastructure.This approach optimizes survivability using models of damage or casualty scenarios. This capability willbe demonstrated in a laboratory hardware in the loop simulation. This project leverages the results of several other ongoing research efforts al ...

"The aim of our Phase II activity is to incorporate the Cohesive Volumetric Plate and Shell (Finite) Elements into LS-DYNA3D, thus enhancing its capabilities in modeling HRAM loading and damage in composite structures. In Phase I, we reported oninterlaminar failure criteria and modes, based on fracture mechanics. A damage-dependent bilinear cohesive element is used to capture the crack initiatio ...

"This Phase I SBIR Project will develop a complete set of guiding documents which shall constitue a roadmap for implementing and deploying the Worldwide C4I for Special Operations Forces Combatant Craft solution. The documentation set will include analysisand results for algorithms in the areas of data compression, and encryption schemes. The document set shall contain the following: Concept of ...

DESCRIPTION (provided by applicant): This application is submitted in response to NCUBIP PAR-01-102, "Development of Novel Imaging Technologies for In-Vivo Imaging". A overall goal of this project is to facilitate routine head/neck imaging at 3T, which at present is limited to head MRI. In Phase I, novel RF coil prototypes capable of high-resolution head/neck imaging in a clinical 3T setting will ...

Strong and durable bonds between rubber and metals are important in many industries. The largest single commercial application is bonding of steel tire cords to sulfur-vulcanized natural rubber (NR) compounds. The current process for bonding steel tire cords to NR compounds requires the plating of brass on the individual filaments. This brass alloy is applied on the running wire as it is being dra ...

"Aetion will leverage proprietary multi-criterial decision-making technology, SFVM, that can be used for generating and evaluating a very large number and range of manufacturing alternatives in parallel, efficiently finding the best options from among them,and presenting the results to the user so that they can understand how the design of prototypes impacts their manufacturability, and to navigat ...

"To maximize situational awareness, while minimizing cognitive overload, automated abductive inference (best-explanation reasoning) will be used to create a changing, "best interpretation" representation of the situation from incoming data. Modeling andsimulation will be used by the abductive inference software for automatic generation of predictions from hypotheses, enabling the continual generat ...

"Aetion Technologies LLC will study the feasibility of applying its SFV decision-support technology to visualization of modeling and simulation processes. The technical and scientific merit will be assessed of applying SFV technology to build up models andobserve them being simulated, in whole or in part. This use of SFV will be evaluated by applying Generic Task methodology to analyze the informa ...