Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Social-Simentor: Interactive Simulation e-Learning Tool to Develop Interpersonal Skills for Individuals with Cognitive Disabilities to Improve Hiring and Retention

    SBC: Access Tech            Topic: N/A

    An interactive application that employs social interactions to teach key social conventions, including appropriate responses, reacting to body language and facial expressions, and the ability to ask for help to facilitate functioning in society

    SBIR Phase I 2005 Department of Education
  2. Capsid assembly inhibitors for the treatment of AIDS

    SBC: Achillion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Current HIV-1 therapy suffers from inadequate viral load suppression due to poor compliance, resistance, and interactions with other drugs and can lead to spread of drug-resistant strains. The current drug cocktails need to include inhibitors of viral components that are likely to slow resistance development. One such target is the HIV-1 capsid, an essential vi ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Nebulizing Eculizumab for intrapulmonary C5 inhibition

    SBC: Alexion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma (manuscript, submitted). Our data demonstrated that C5 inhibition has profound effects at all the critical poi ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Salivary Gland System for the Production of Therapeutics

    SBC: American Integrated Biologics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to investigate the feasibility of the ruminant salivary gland as a system for the production of therapeutic human proteins. Protein therapeutics is currently in increased demand for the treatment of disease. Existing production systems have limitations such as low capacity, high cost and lack of appropriate post-tran ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. System for Multiplex Real-Time Analysis of Nucleic Acids

    SBC: CIENCIA INC            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this Phase I project is to test the feasibility of biochip imaging system which will vary the temperature of the arrays and perform real-time imaging and quantification during PCR and probe meltoff. A specialized microarray of discrete hydroge! Compartments for array-based PCR amplification will be tested with the prototype instrument. The ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Plasmonic Fluorescence Microarray Detection System

    SBC: CIENCIA INC            Topic: N/A

    DESCRIPTION (provided by applicant): The long term objective of the proposed project I is to develop an affordable, highly parallel and highly sensitive detection system for protein and DMA chip applications. This system is based on a novel fluorescence detection technology with the potential for 10- to 1000-fold higher sensitivity than current state of- the-art fluorescence imaging systems. Impo ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Mapping disease-specific human protein networks

    SBC: Curagen Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): While the human genome sequence is known, medical advances will require knowledge of how individual genes and proteins assemble into functional biological networks. These networks are built in part through physical interactions between proteins. Protein interaction networks can now be probed using highthroughput experimental methods, yet challenges remain: dat ...

    STTR Phase I 2005 Department of Health and Human Services
  8. Development of a Genetic Therapy for CF in a CF Rabbit

    SBC: EVERGEN BIOTECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of transgenic mouse models for cystic fibrosis (CF) has been an important contribution to our understanding of CF and of CF transmembrane conductance regulator (CFTR) function. However, because of the dissimilarity between mouse and human anatomy and physiology, there are limitations in what can be discerned about CF pathology and in development ...

    STTR Phase I 2005 Department of Health and Human Services
  9. Physiogenomic Arrays for Clinical Neuropsychiatry

    SBC: GENOMAS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Neuropsychiatric and neurodegenerative disorders such as schizophrenia, Alzheimer's disease, and depression are genetically complex diseases with multiple contributing genes. There is an urgent need for innovative technologies to study the multi-gene etiology of these disorders for early diagnosis, prevention, and treatment. Advances in the Genomas PhysioGenomi ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Gene Markers: Antipsychotic-Induced Metabolic Syndrome

    SBC: GENOMAS, INC.            Topic: N/A

    DESCRIPTION (PROVIDED BY APPLICANT): This Phase I SBIR Program will develop genetic diagnostic products to improve the safety of atypical antipsychotics (e.g. olanzapine) for treating psychiatric disorders, including schizophrenia. Atypical antipsychotics are prescribed as long-term treatments for an increasing number of indications even to adolescent's patients. In up to 50% of patients, these hi ...

    SBIR Phase I 2005 Department of Health and Human Services
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