Award Data

DESCRIPTION (provided by applicant): We propose to develop an inexpensive high-throughput means of selecting and identifying antibodies to both unmodified and modified protein, peptide, and non-peptide antigens. The specific goals of this proposal are to complete a proof-of-concept using aqueous droplets in an oil emulsion for identification and isolation of scFv antibodies. Compartmentalization ...

DESCRIPTION (provided by applicant): Our recent series of innovative randomized trials evaluating the efficacy of various strategies for training clinicians to use evidence based therapies in alcohol and drug abuse has indicated that while both in-person workshop and computer-assisted training can impart the skills necessary to deliver Twelve Step Facilitation, they are by no means sufficient in e ...

DESCRIPTION (provided by applicant): This SBIR Phase I project will determine the feasibility of applying polypeptide multilayer nanofilm technology to synthetic biomatrix development and commercialization. These nanofilms are a type of surface coating for cell and tissue culture. Immediate in vitro uses of synthetic biomatrix materials include many areas of basic medical research, diagnostic test ...

DESCRIPTION (provided by applicant): Reducing protein deposition events is essential for slowing the progression of Alzheimer's disease (AD), especially A 1-42 peptide oligomers that accumulate inside and outside neurons and cause functional compromise. Finding a strategy to reduce A oligomeric assemblies is widely thought to be the key objective for treating AD. Accumulation of A peptides is on ...

DESCRIPTION (provided by applicant): Anastomotic failure is one of the most feared complications of gastrointestinal surgery due to the resultant morbidity and mortality. Failure of an anastomosis, or intestinal junction, can cause a spectrum of morbidities to the patient including local abscess formation - requiring procedural drainage, tumor recurrence, debilitating pain, dysfunctional defecatio ...

DESCRIPTION (provided by applicant): Tissue engineering currently has little discipline in assessing the efficacy of biomaterials through in vivo experiments. This lack of discipline poses a serious challenge to the community as it will soon be inundated with scaffold biomaterials and alternative progenitor and stem cells. The community needs to establish a systematic way of evaluating which combi ...

DESCRIPTION (provided by applicant): This project aims at developing software technology capable of automating bone histomorphometry, which at the moment is mostly done manually through cumbersome and laborious interactive processes. Our plan is to use state-of-the-art image processing techniques to automate detection, measurement and quantification of biological effects directly over the stained ...

DESCRIPTION (provided by applicant): Background: Over the past five years, the University of Connecticut together with its start-up spin-off corporation (Biorasis Inc.) has been developing a totally implantable biosensor platform (0.5 mm x 0.5 mm x 5 mm) capable of continuously monitoring glucose. The underlying principle in developing this miniaturized sensor hinges on extreme miniaturization uti ...

DESCRIPTION (provided by applicant): The proposed research would determine the feasibility of using proven energetic materials as active packaging components for integration into primary packaging, thereby providing a controllable and non invasive means of altering the atmosphere inside the package after it has been processed and hermetically sealed. This active packaging technology can be used i ...

DESCRIPTION (provided by applicant): The long-term goal of this project is a small molecule therapeutic of benefit to patients with rheumatoid arthritis (RA), which will act by reducing the inflammatory response triggered by macrophage migration inhibitory factor (MIF). RA afflicts up to 4 million people in the U.S., and the healthcare and indirect costs of this disease are significant. While sev ...