Award Data

Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

In this project, researchers will develop a prototype of a web-based tool through which English Learners (EL) can practice conversation with an automated avatar. The Speaking and Listening Learning System will provide support, feedback, and will adapt to the conversational level of students. At the end of Phase I, in a pilot study with 20 EL students in grades 1 and 2, the researchers will examine ...

New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

PROJECT SUMMARYMitral regurgitationMRis the most prevalent valvular heart disease in the U Saffecting approximatelyof the populationThere aremillion patients in the US with moderate to severe MR requiring treatmentHoweveronly approximatelypatients in the U Sundergo surgery for MR each year due to concerns about procedural complexity and patient safetyThere is great enthusiasm among the heart valve ...

PROJECT SUMMARY Current treatment options for many skin diseases especially rare diseases fail to address the underlying causative pathophysiologiesIn the case of genetic mutations that cause loss of function mutationssupplementing the missing protein is a viable approach to treatmentHoweverdelivery of functional protein to the target keratinocytes presents a significant challengemoreoverthe cost ...

PROJECT SUMMARY ABSTRACT The host T cell response to HBV is vigorous and multi specific in acutely infected patients who clear the virusbut it is weak and more narrowly focused in those who become chronically infectedThereforealthough the human immune response is capable of eliminating the infectionit often fails to do soTherapeutic immunization to induce an immune response sufficient to control t ...

Project SummaryAbstract Relatedness to MissionApplication aligns with multipleNINR SBIR goalsGTechnologies to treat chronic wounds that fail to healspecificallydiabetic ulcersBDevices that improve the acceptance and use of assistive devicesBDevices that improve delivery of care to persons who have restricted movement due toperipheralvascular diseaseto allow them to better self manageDTechnologies ...

The objective of this Phase I SBIR is to establish the proof of concept for a device and method that uses unique biometric signatures to provide an objective measure of pain and analgesic effectBackgroundThe overall prevalence of pain in the United States is substantial withof the adult population experiencing chronic painMoreoverthe rates of chronic pain are expected to continue to rise over time ...

Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of blocking MCJalso called DnaJCto overcome acute acetaminophen liver toxicityAcetaminophen or APAPfrom acetyl paraaminophenolis a common drug used to address pain and feverIn the US aloneaboutpatients per year are admitted to intensive care units with APAP induced liver injury and close toof these patients undergo ...