Award Data

An interactive application that employs social interactions to teach key social conventions, including appropriate responses, reacting to body language and facial expressions, and the ability to ask for help to facilitate functioning in society

DESCRIPTION (provided by applicant): Current HIV-1 therapy suffers from inadequate viral load suppression due to poor compliance, resistance, and interactions with other drugs and can lead to spread of drug-resistant strains. The current drug cocktails need to include inhibitors of viral components that are likely to slow resistance development. One such target is the HIV-1 capsid, an essential vi ...

DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma (manuscript, submitted). Our data demonstrated that C5 inhibition has profound effects at all the critical poi ...

DESCRIPTION (provided by applicant): The objective of this project is to develop an anti-tissue factor antibody, Sunol-cH36, as a treatment for Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The association between coagulation and inflammation has been well established and a central role in the coagulopathy of ALI/ARDS has been attributed to tissue factor (TF). TF binding ...

DESCRIPTION (provided by applicant): The need to develop novel, cost effective manufacturing processes to produce therapeutic antibodies commercially will continue to be of considerable and growing interest to biopharmaceutical and medical industries. The long-term objectives related to this application are to develop novel manufacturing processes using stable transgenic plants, namely Arabidop ...

DESCRIPTION (provided by applicant): The long-term objective of this project is to develop small molecule inhibitors of MHC class II activity for the treatment of rheumatoid arthritis (RA). The strong genetic association between specific MHC class II alleles, such as HLA-DR molecules containing the shared epitope, and susceptibility to RA provides support to a mechanism in which disease-associate ...

DESCRIPTION (provided by applicant): The overall objective of this proposal is to investigate the feasibility of the ruminant salivary gland as a system for the production of therapeutic human proteins. Protein therapeutics is currently in increased demand for the treatment of disease. Existing production systems have limitations such as low capacity, high cost and lack of appropriate post-tran ...

DESCRIPTION (provided by applicant): Microarrays are a powerful way to measure the impact of contaminants present in the environment. In this proposal, we will sequence genes from grass shrimp and sheepshead minnows, make trial microarrays from these genes, and show the expression patterns that result from exposure to contaminants that are present in the environment. Measurement and analysis of c ...

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Stroke is the second leading cause of death worldwide and the primary cause of serious, long-term disability and nursing home admissions. The absence of clinically useful diagnostics has severely impeded effective management and treatment of acute ischemic stroke. Currently available diagnostics are either expensive and/or unreliable and there are no simple, rapid, non-invasive tests to diagnose a ...