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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Social-Simentor: Interactive Simulation e-Learning Tool to Develop Interpersonal Skills for Individuals with Cognitive Disabilities to Improve Hiring and Retention

    SBC: Access Tech            Topic: N/A

    An interactive application that employs social interactions to teach key social conventions, including appropriate responses, reacting to body language and facial expressions, and the ability to ask for help to facilitate functioning in society

    SBIR Phase I 2005 Department of Education
  2. Capsid assembly inhibitors for the treatment of AIDS

    SBC: Achillion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Current HIV-1 therapy suffers from inadequate viral load suppression due to poor compliance, resistance, and interactions with other drugs and can lead to spread of drug-resistant strains. The current drug cocktails need to include inhibitors of viral components that are likely to slow resistance development. One such target is the HIV-1 capsid, an essential vi ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Nebulizing Eculizumab for intrapulmonary C5 inhibition

    SBC: Alexion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma (manuscript, submitted). Our data demonstrated that C5 inhibition has profound effects at all the critical poi ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Suspension arrays detection/quantification of antibodies

    SBC: ALPHA UNIVERSE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): In modern medicine and science there is a growing need for the ability to profile composition of such bodily fluids as serum and saliva. Microarray chip technology has potential for delivering such ability. This technology has already changed pharmaceutical research. So far, however, this technology has not been used extensively in protein-focused studies. The ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Approach for amplification of molecular signals

    SBC: ALPHA UNIVERSE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Antibody-based detection systems have been used for years in clinical diagnostics and environmental monitoring for the detection and identification of pathogenic agents. Recent advances in the field of low-level antigen detection utilize the DNA polymerase-mediated signal amplification approach that provides a substantial enhancement in detection sensitivity ov ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Salivary Gland System for the Production of Therapeutics

    SBC: American Integrated Biologics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to investigate the feasibility of the ruminant salivary gland as a system for the production of therapeutic human proteins. Protein therapeutics is currently in increased demand for the treatment of disease. Existing production systems have limitations such as low capacity, high cost and lack of appropriate post-tran ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Miniature sternal skin-attached hot flash recorder

    SBC: BAHR MANAGEMENT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The characteristics of existing sternal skin conductance monitors that hinder use under ambulatory conditions and for long tern data collection are that they are too bulky to be cosmetically acceptable, have distracting wires, and weigh too much. We propose to characterize hot flashes by measuring the frequency, timing, and the amplitude of hot flashes using st ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Generic Fluorescent HTS Assay for Protein Kinases

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are more than 400 distinct protein kinases encoded in the human genome; elucidating their role in disease and identifying selective inhibitors is a major pharma initiative. Kinase malfunction has been linked to all of the most important therapeutic areas, including cancer, cardiovascular diseases, inflammation, neurodegenerative diseases, and metabolic d ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  9. Microfluidic Reconstituted Mammary Tissue System

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Discovery of improved therapies for breast cancer will require assay systems that accurately recapitulate the cellular signaling of intact mammary tissue. To reconstitute mammary tissue structure and function faithfully in vitro, we will develop a microfluidic device for co-culturing human mammary epithelial and stromal cells in adjacent, separately addressable ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Chemical/Biological Agent Non-Intrusive Detection

    SBC: Brandt Innovative Technologies, Inc.            Topic: DTRA05005

    We propose to demonstrate the ability to non-evasively probe the characteristics of material properties using acoustical waves through thermal conversion of a remote laser pulse. The advantages of proposed system as an inspection and identification technique are: 1) Non-contact: Sensor does not require contact with container 2) Stand-off: Sensor could be located many meters away from container 3 ...

    SBIR Phase I 2005 Department of DefenseDefense Threat Reduction Agency
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