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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Novel anti-neuroinflammatory drug for aneurysmal subarachnoidhemorrhage (aSAH)
SBC: IMMUNOCHEM THERAPEUTICS LLC Topic: 106ABSTRACT Nontraumatic (aneurysmal) subarachnoid hemorrhage (aSAH) is one of the most dangerous forms of stroke, with almost half of victims dying within the first month after diagnosis, and a half of the survivors becoming severely disabled and incapable of living independently. This proposal is focused on addressing a common pathophysiological mechanism of neurocognitive outcomes of aSAH and othe ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Development of a Diagnostic Test for Eosinophilic Chronic Rhinosinusitis
SBC: GLYCOMIRA, LLC Topic: NIAIDPROJECT SUMMARYThe goal of this proposal is to optimize and clinically validate a new diagnostic test for eosinophilic chronic rhinosinusitis (eCRS) at the point-of-care, improving the efficiency, value, and accessibility of personalized medicine. eCRS affects up to 5 million Americans and is characterized by varying degrees of sinonasal and peripheral eosinophilia, linked to treatment responsiven ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
In vivo Evaluation of USP30 Inhibitors in Models Relevant to Parkinson's Disease
SBC: VINCERE BIOSCIENCES INC Topic: 999ABSTRACT Existing treatments for Parkinson’s disease (PD), which affects 10 million people worldwide, primarily augment dopaminergic neurotransmission to provide symptomatic benefit. No current therapy can slow or stop the progression of PD. We propose a drug discovery platform to develop small molecules targeting the parkin-USP30 mitophagy pathway, which represents a key regulator of mitochondr ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
PANK Activators for the treatment of pantothenate kinase-associated neurodegeneration
SBC: Virtus Therapeutics Corporation Topic: NINDSSUMMARY Pantothenate kinase-associated neurodegeneration, PKAN, is a rare progressive neurodegenerative disorder associated with iron accumulation in the brain. The disease causes early immobility and often death by early adulthood. PKAN is caused by mutations in one of four human pantothenate kinase genes, PANK2 gene, which encodes a mitochondrial pantothenate kinase. Consistent with the clinical ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Machine learning optimized autoimmune therapeutics with a focus on Type 1 Diabetes
SBC: THINK THERAPEUTICS, INC. Topic: NIAIDProject Summary We propose to develop a new immunogenicity assay and machine learning based framework for creating tolerization vaccines for autoimmune diseases with improved population coverage. In collaboration with Harvard University and the University of Massachusetts Chan Medical School Diabetes Center of Excellence we will develop a new assay, the Multiplexed Multi-antigen Activation Assay ( ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
New target and new therapy for severe Covid-19 and viral hyperinflammation damage: renalase and renalase agonists
SBC: BESSOR PHARMA, LLC Topic: NIAIDAbstract The SARS-CoV-2 host response is associated with wide-ranging immuno-inflammatory derangements and tissue injury. We are developing an innovative therapeutic, BP-1002, to both blunt inflammatory cytokines and protect tissues. BP-1002 has the potential to prevent organ injury and deaths from COVID-19, regardless of viral variants. BP-1002, is a renalase (RNLS) agonist - a recently discovere ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Discovery and development of OGG1 activators as precision drugs for modification of Alzheimer's disease progression.
SBC: LUCIOLE PHARMACEUTICALS, INC. Topic: RPROJECT SUMMARY Alzheimer’s disease (AD) is a leading cause of dementia with 1 in 85 adults affected worldwide. The lack of disease-modifying therapies or mechanistic biomarkers to reliably monitor treatment are key unmet needs. Current standard of care (SoC), i.e., acetylcholinesterase or NMDA receptor blockade, provides limited symptom-relief. Current evidence indicates that an inter-related, ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Targeting the eNAMPT/TLR4 pathway to reduce Inflammatory Bowel Disease severity
SBC: AQUALUNG THERAPEUTICS, CORP Topic: 300ABSTRACT Inflammatory bowel disease (IBD) is a debilitating disease (without curative therapies) that is critically influenced by dysregulated inflammatory pathways. This A0 R42 STTR application focuses on a highly novel humanized monoclonal antibody (mAb), ALT-100, to target and neutralize eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a damage-associated molecular pattern protein ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Controlled Gradient Release of Biologics: Enhanced Nerve Conduit for Long‐Gap Injury Repair
SBC: Pioneer Neurotech Inc. Topic: 106Project Summary / Abstract Nerve injuries arising from trauma, disease, or as a surgical necessity, lead most often to permanent loss of some or all functions mediated by the injured nerves. 50,000 peripheral nerve procedures are performed every year in the US, and 300,000 across Europe. After complete transection of a nerve, the optimal clinical procedure for nerve repair remains the surgical end ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of antibody drug conjugates as pan-filo antivirals
SBC: MICROBIOTIX, INC. Topic: NIAIDProject Summary Filoviruses cause severe hemorrhagic fevers and are among the deadliest human viruses with no approved treatment or prophylactic options. Periodic outbreaks, such as the recent epidemic of Ebola virus (EBOV) in West Africa, exhibit mortality rates ranging from 50-90%. They are classified as “Category A priority bioweapon agents” by the Centers for Disease Control and Prevention ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health