Award Data

PROJECT SUMMARY Migraine is a highly prevalent condition with an extraordinarily negative impact on quality of life and represents a heavy socioeconomic burden to the societyprimarily because of decreased working efficiency and workdays lostManagement of migraine has become increasingly pharmacological during recent yearsWhile several therapeutic options existmost of the prophylactic drugs current ...

PROJECT SUMMARY Traumatic brain injuryTBIrepresents a significant societal and economic impactTo datethere are no FDAapproved pharmacotherapies to prevent or reverse TBIThe standard of care in an emergency setting focuses first on stabilizing the patient and secondly on management of cerebral hemodynamicsThe patient may undergo surgery to remove hematomasrepair skull fracturesand relieve intracran ...

Project Summary AbstractUpwards ofmillion individuals are afflicted by chronic pain in the US alonewithmillion of these individuals suffering from neuropathic painOn a global scalechronic pain affectsbillion individualswithwho endure lower back painFrom a clinical perspectivethe International Association for the Study of Pain approximates thatinpatients present with painand on an annual basisinpat ...

PROJECT SUMMARY Diseases of the ocular surface are among the top reasons for visits to eye care practitionersThese conditions can severely affect eyesight and quality of lifeSymptoms may include blurry visiondiscomfort or painredness and itchingand in severe casesblindness due to corneal scarringMany ocular surface diseases are initiated by loss of tear film homeostasis and can be grouped under a ...

ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tickIxodes scapularisby targeting tick salivary proteinsSalpscritical for tick feedingIscapularis Salps provide functions critical for evading host defense responses detrimental to the tickFurtherthese salivary functions are also co opted by tick transmitted pathogens to ensure their survival in ...

Project Summary Multiple sclerosisMSis a neurodegenerative disease in which myelin of the central nervous systemCNSis destroyed by a self reactive immune responseThis demyelination is accompanied by the death of the myelinating cells themselvesthe oligodendrocytesRepeated bouts of demyelination leave the denuded CNS neurons vulnerable to degradation and is the major cause of neuronal dysfunction a ...

PROJECT SUMMARY Asthmacharacterized by airways obstruction with symptoms of wheezingshortness of breathchest tightness and consequently coughremains a significant health problemWhile advances in bronchodilatorcorticosteroid and Thtargeting therapy allow for well controlled asthma in a large population of patientssubjects with severecorticosteroid resistant asthma require frequent hospitalizations ...

PROJECT SUMMARY Cognitive decline and deterioration of long term cognitive performance are major side effects of CNS cancer treatmentBrain metastases are the most common CNS malignancies and a common cause of morbidity and mortality in aboutof all cancer patients with systemic diseaseaffecting overpatients in the US annuallyAs most systemic chemotherapy agents do not cross the blood brain barriert ...

PROJECT SUMMARY ABSTRACT Every year in the United States aboutof theinfants born extremely prematureandltweeks gestational age and andltg birth weightELGAdevelop intraventricular hemorrhageIVHIVH is associated with high risk for cerebral palsy and significant intellectual disabilitycausing lifelong implications for affected children and their families and considerable economic burdenIVH is caused ...

PROJECT SUMMARYMalaria is one of the world s major public health threatsThe disease is transmitted when an infected female Anopheles mosquitowhile probing for a blood mealinjects saliva together with Plasmodium sporozoites into the skin of the vertebrate hostTo datea highly effectivesafe and FDA approved human vaccine against malaria has not been developedThe most established malaria vaccine candi ...