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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Astrocyte activation by small-molecule ADORA3 agonists: a novel therapy for Alzheimer's disease

    SBC: ASTROCYTE PHARMACEUTICALS INC.            Topic: NIA

    PROJECT SUMMARY Alzheimerandapos s diseaseADis an area of significant unmet need that creates a national burden of$billion annuallyAD is the leading cause of dementiaaffectingof Americans over the age ofDemographic shifts and the age related nature of AD will soon place this disease as the costliest health care expenditure in the U Swith a projected impact of $trillion per year byCurrent therapies ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. PAR2 Pepducins as a Novel Treatment of Idiopathic Pulmonary Fibrosis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NHLBI

    Idiopathic pulmonary fibrosisIPFthe most common of the interstitial lung diseasesoccurs in aboutpeoplewithnew cases diagnosed annually in the USThe typical clinical course is a progressive fibrotic disease characterized by scarring and `honeycombingandaposof the lungs causing an irreversible loss of the tissueandapos s ability to transport oxygenCo morbid pulmonary hypertension is commonly seen in ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. O-Glycan-dependent Immunotherapy for Cancer

    SBC: GLYTR THERAPEUTICS, INC.            Topic: 102

    Abstract For decadesthe treatment of cancer has relied on surgical resectionchemotherapy and or radiotherapyRecentlya number of immune based therapies have provided promising new approaches for cancer treatmentThe two most potent immunotherapies are monoclonal antibodymABbased bi specific proteinseg Bispecific T cell engagersBiTEand engineered Chimeric Antigen Receptor T cellsCAR TBoth act by indu ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Discovery of Zika virus therapeutics using a replicon assay

    SBC: MICROBIOTIX, INC.            Topic: R

    ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Inter-examiner Agreement of a Novel Device for the Measurement of Cervical Dilation in Labor: A Randomized Controlled Trial

    SBC: Elm Tree Medical Inc.            Topic: NICHD

    Measurement of cervical dilation during late pregnancy and labor informs decisions in the management of labor and deliveryPrior published research suggests that practitioners are onlytoaccurate when judging cervical simulatorsWhen measuring laboring womentwo practitionersandaposmeasurements agree onlyof the timeDrEva Martin of Elm Tree Medical Incdeveloped a novel deviceDilaCheckto enable practiti ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Image Analysis Tools for mpMRI Prostate Cancer Diagnosis Using PI-RADS

    SBC: ZMK Medical Technologies, Inc.            Topic: 102

    ABSTRACTProstate cancerPCais one of the most commonly occurring forms of canceraccounting forof all cancer in menMulti parametric magnetic resonance imagingmpMRIhas led to improved capabilities for detectinglocalizingand staging PCaCombined with image guided prostate biopsympMRI has helped to improve diagnosis of clinically significant PCawhich helps to reduce mortality as well as unnecessary biop ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Innovative Nose-to-Brain Anticancer Drug Transport Facilitated by NEO100

    SBC: NEONC TECHNOLOGIES INC            Topic: 102

    Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A novel wearable platform to assess cognitive-motor performance

    SBC: BIOSENSICS LLC            Topic: NIA

    ABSTRACT The recent shift in Alzheimer s diseaseADclinical research from clinical diagnosis toward the goal of developing neuroprotective therapies has highlighted the need for a robust and rapidly administered cognitive assessment tool capable of identifying individuals in the earliest stages of cognitive decline and measuring subtle changes in cognitive motor performance over timeIn this context ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Developing novel combination therapies for HSV genital infection.

    SBC: CASTERBRIDGE PHARMACEUTICALS INC            Topic: NIAID

    Herpes simplex virusesandHSVHSVcause a wide range of serious diseasesincluding oral genital lesionscorneal blindness and eczema herpeticumHSVand HSVare both transmitted sexually and can infect babies during birthTherapy for HSV relies primarily on nucleoside analogs such as acyclovirACVwhich are insufficiently effectiveand resistant viruses are becoming common among immunosuppressed personsTherefo ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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