Award Data

Physical Sciences Inc. (PSI), in collaboration with Wayne State University (WSU), proposes to develop a low-cost blast surrogate testing device that can be used to evaluate next generation personal protective equipment (PPE). Although new material advancements could be used to mitigate the blast wave through improved PPE design, a more advanced test surrogate is needed to inform PPE design decisio ...

Precise detection of biomarkers can stratify the disease progression. A set of gene biomarkers can provide high-resolution specificity of the disease complexity. For example, Cytochrome P450 single nucleotide polymorphism (SNP) genes (such as CYP2D6 and CYP2C19) are linked to the metabolization rate of clinically used drugs (~25%). Detection of these polymorphic genes is essential to assess drug m ...

Tissue repair and wound closure have traditionally been performed using mechanical methods, which while necessary to bring the wound surfaces into apposition and provide sufficient strength to avoid dehiscence, are associated with a variety of downstream effects that can prove deleterious to the ultimate repair. An alternative light-based approach called Photochemical Tissue Bonding (PTB) uses che ...

Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn) including Dr. Robin Bogner, with expertise in pharmaceutical freeze drying and sustained release for novel pharmaceutical formulations, and Dr. Carolyn Teschke, with expertise in bacteriophage biology, proposes to demonstrate long-term stability of bacteriophages between storage temperatures of -20°C and +45 ...

Multiple orthotics and prosthetics users would benefit from sensors that can collect physiological information from the user and transmit it wirelessly to the prosthesis. For example, prosthetic sockets have long been one of the primary sources of complaints for both upper- and lower-limb amputees. However, if a user decides to utilize osseointegration in place of wearing a socket, there would no ...

The primary objectiveis to develop acommercially-viable prototype of theslopeadaptive prosthesis design and to iteratively improvethe design based on ISO standards testingand rigorous usein human subject field trials. The proposed work will build upon knowledgegained in PhaseI of the project,which established feasibility for this design approach in alightweight, passive hydraulicfoot-anklesystem. ...

We have developed a novel low-cost, multi-functional blood coagulation sensor that can measure a patient’s coagulation status within less than 10 minutes using a 25mL drop of blood. This device addresses the critical unmet need to identify and manage patients with an elevated risk of life-threatening bleeding or thrombosis, the major causes of in-hospital preventable death. In addition, our inno ...

Information regarding the state of Warfighters (e.g., fatigue, distraction, stress) and of the team (e.g., cohesion) can greatly impact mission planning and the likelihood of mission success. Harnessing neural data collected via functional near-infrared spectroscopy (fNIRS) can be a game-changing tool for assessing individual and team states, but current technologies do not support continuous neur ...

Deep Convolutional Neural Networks (DCNNs) have become ubiquitous in the analysis of large datasets with geometric symmetries. These datasets are common in medicine, science, intelligence, autonomous driving and industry. While analysis based on DCNNs have proven powerful, uncertainty estimation for such analyses has required sophisticated empirical studies. This has negatively impacted the effect ...

High concentrations of supplemental oxygen are used routinely by pilots and divers prior to and during missions to prevent and treat decompression sickness, avoid detection during covert operations, and to support oxygenation following pulmonary injury. Due to pulmonary oxygen toxicity (PO2T), exposure limits are imposed to prevent damage to pulmonary tissues. Current policy focuses on preventing ...