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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. A2A AR Agonists as Adjunct Therapy Against S. aureus Sepsis

    SBC: ADENOSINE THERAPEUTICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This is a phase I STTR application to study the efficacy of selective adenosine A2A receptor (A2AR) agonists developed in the laboratories of Adenosine Therapeutics (ATL) in models of Gram-positive bacterial sepsis which will be conducted in the University of Virginia (UVA) laboratories of Dr. Michael Scheld, an expert in the field of infectious disease. Sepsis ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. A2a AR Agonists for Rheumatoid Arthritis

    SBC: ADENOSINE THERAPEUTICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This is the first revision of a phase I STTR proposal to develop new therapies for the treatment of rheumatoid arthritis (RA). It is collaboration between a biotechnology company, Adenosine Therapeutics, LLC (ATL) based in Charlottesville, VA, and the University of Virginia laboratory of Dr. Donald L. Kimpel, a Rheumatologist experienced in the study of RA. Hum ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Adaptive camera to display mappings using computer vision

    SBC: POLAR RAIN, INC.            Topic: N/A

    The video surveillance industry is experiencing dramatic change with the move from analog to digital video. Command centers need to have coordinated viewing of multiple camera feeds at one time, and the ability to switch automatically between feeds and display relevant patterns. Conventional security control rooms include a bank of monitors connected through a switch to an array of security camera ...

    STTR Phase I 2006 Department of Homeland Security
  4. A 3-D Interactive Atlas of the Human Skull

    SBC: BROWN AND HERBRANSON IMAGING            Topic: N/A

    DESCRIPTION (provided by applicant): Broad long term objectives and specific aims: The long-term objective of this project is to develop a digital anatomical research resource library of very high-resolution computational models, and imaging data sets. Our objective is to produce an anatomical library otf the complete human skeleton. The implications of this project, both scientific and social are ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. A Genetic Test for Drug-Induced Dyskinesia Risk

    SBC: KOVOGEN            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to develop a genetic test, involving the protein, RGS9, to identify patients that are at risk for developing tardive dyskinesia (TD) or L-DOPA induced dyskinesia (LID). Antipsychotic drugs have revolutionized the treatment of schizophrenia and psychotic disorders but a debilitating side-effect of "typical" antipsychotics is TD, ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. A HUMAN MONOCLONAL COCKTAIL FOR RSV IMMUNOTHERAPY

    SBC: MAPP BIOPHARMACEUTICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The central goal of this application is to develop a combination product comprising two fully human monoclonal antibodies (mAbs) produced in plants for the prevention of serious disease caused by respiratory syncytial virus (RSV). RSV causes high morbidity and mortality in certain neonate populations as well as in the elderly and in bone marrow transplant patie ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma

    SBC: Algen Biotechnologies Inc            Topic: 400

    AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma PROJECT SUMMARY Drug discovery is a laborious, time-consuming, and expensive undertaking for biopharma. Oncology is especially difficult with new drugs in clinical trials having just 3.4% probability of success. This application addresses significant challenges of traditional drug target discover ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Allosteric Drug Discovery using Quantum Cascade Laser based Anisotropic THz Microscope (QCL-ATM)

    SBC: LONGWAVE PHOTONICS LLC            Topic: 400

    Allosteric Drug Discovery using Quantum Cascade Laserbased Anisotropic THz Microscope (QCL-ATM) Proposal in Response to NIH/NIGMS STTR PA-20-265 This STTR will result in a commercially viable instrument that will enable critical research in allosteric drugs and protein dynamics. To date allosteric inhibitors are largely found serendipitously. Anisotropic THz microspectroscopy (ATM) uniquely measur ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Amelioration of opioid withdrawal-induced anxiety and craving with heterodyned whole body vibration

    SBC: PhotoPharmics, Inc.            Topic: NIDA

    PROJECT SUMMARY Opioid use disorder (OUD) is a rising problem in the United States and around the world, with pain and stress being major factors for initial drug seeking and relapse. The mesolimbic dopamine (DA) system originating in the midbrain ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc) in the striatum is an important nexus for the rewarding properties of opioids ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically, the proposed innovations aim to achieve streaming of high-resolution holograms at up to 10,000 frames per second (fps) to enable closed-loop optogenetic control.Optical imaging and photostimulation have emerged as compl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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