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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain

    SBC: Ripple, LLC            Topic: 999

    Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of A Narrow Spectrum Anti-Tubercular Agent

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    Abstract Complex and lengthy treatment regimens coupled with rising drug resistance underscore the urgent need for new and better drugs to treat tuberculosisTBcaused by the bacterium Mycobacterium tuberculosisMtbCurrent treatment regimens for drug resistant TB involve the use of costlyless effectiveand toxic drugs that must be continued for up tomonthsThe work proposed here focuses on a proprietar ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Targets of Acquired Tick-Resistance As Anti-Tick Vaccines

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tickIxodes scapularisby targeting tick salivary proteinsSalpscritical for tick feedingIscapularis Salps provide functions critical for evading host defense responses detrimental to the tickFurtherthese salivary functions are also co opted by tick transmitted pathogens to ensure their survival in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Potent oral chitotriosidase-1 inhibitors as a novel therapy for sarcoidosis

    SBC: ONCOARENDI THERAPEUTICS LLC            Topic: NHLBI

    Abstract Sarcoidosis is a systemic disease with large unmet medical needand unknown causecharacterized by the formation of immune granulomas in various organsmainly the lungs and the lymphatic systemAboutof patients develop a chronic or progressive disease necessitating long term treatmentCurrent therapiesincluding the standard of caresystemic corticosteroidsdo not prolong survival and only have l ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Neonatal Jaundice Treatment Accelerator by Circumferential Redirection of Unused Phototherapy Light onto the Infants Untreated Skin Surface

    SBC: Arbor Grace Inc.            Topic: NICHD

    PROJECT SUMMARY ABSTRACT Neonatal jaundice continues to be a significant global problem affectingof preterm andof term neonates while severe neonatal jaundice affects at leastneonates annuallyJaundice and jaundice related complications like Kernicterus Spectrum DisorderKDSare gaining recognition among the worldandapos s health policy leaders as an important area for further research and developmen ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Immunization with mosquito AgTRIO protein to prevent malaria

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYMalaria is one of the world s major public health threatsThe disease is transmitted when an infected female Anopheles mosquitowhile probing for a blood mealinjects saliva together with Plasmodium sporozoites into the skin of the vertebrate hostTo datea highly effectivesafe and FDA approved human vaccine against malaria has not been developedThe most established malaria vaccine candi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Calpastatin Peptide-based Calpain Inhibitor as a Traumatic Brain Injury Therapeutic

    SBC: NEUROTHERANOSTICS, INC.            Topic: 101

    AbstractTBI is a leading cause of death and long term disability worldwideAlthough TBI is a significant medical crisisthere are no FDA approved pharmacological therapies that have been shown to improve functional outcomesThe long term goal of this project is to improve the immediate and long term outcomes of patients inflicted with severe TBISuccessful translation of the therapy to the clinical ca ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Next-Generation, Efficient, Fully Automated, High-Definition 3D Patient Treatment Verification System for Stereotactic Radiation Therapy,Radiosurgery and Particle Therapy

    SBC: MGS RESEARCH INCORPORATED            Topic: 101

    The GoalTo improve patient safety and outcomes for all modalities of external beam radiation therapy in a cost effective manner by using a new type of HDD pre treatment Patient Specific Quality AssurancePSQAProduct to be Developed by the end of Phase IIThe CrystalBallSystemwill consist of a fully robotized fast laser CT of low cost reusable radiochromic polymer gel dosimetersIt will detect and cor ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Combination Therapy to Treat Biofilm-based Pneumonia Infections

    SBC: TSRL, INC.            Topic: NIAID

    Abstract Bronchiectasis is a lung pathology characterized by a permanent dilation of the bronchi and is associated with a chronic coughsputum production and recurrent respiratory infectionsCystic fibrosisCFis one of the best understood inherited conditions that leads to progressive bronchiectasischronic bacterial infection and premature mortalityBoth non CF bronchiectasisNCFBand CF have increased ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Improved Ratiometric Voltage-Sensitive Dyes for In-Vitro and In-Vivo Imaging of Brain Electrical Signaling

    SBC: Potentiometric Probes LLC            Topic: 101

    Project Summary Abstract Potentiometric Probes Voltage sensitive dyes can be applied to brain cells and tissue to study the electrical signals used by the brain to functionThe fluorescent dye molecules light up under a microscope and convert tiny electrical signals to measurable changes in light intensityVirtually all neurological disorders involve changes in the brain s normal electrical activity ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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