Award Data

ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tickIxodes scapularisby targeting tick salivary proteinsSalpscritical for tick feedingIscapularis Salps provide functions critical for evading host defense responses detrimental to the tickFurtherthese salivary functions are also co opted by tick transmitted pathogens to ensure their survival in ...

PROJECT SUMMARY ABSTRACT Neonatal jaundice continues to be a significant global problem affectingof preterm andof term neonates while severe neonatal jaundice affects at leastneonates annuallyJaundice and jaundice related complications like Kernicterus Spectrum DisorderKDSare gaining recognition among the worldandapos s health policy leaders as an important area for further research and developmen ...

PROJECT SUMMARYMalaria is one of the world s major public health threatsThe disease is transmitted when an infected female Anopheles mosquitowhile probing for a blood mealinjects saliva together with Plasmodium sporozoites into the skin of the vertebrate hostTo datea highly effectivesafe and FDA approved human vaccine against malaria has not been developedThe most established malaria vaccine candi ...

Abstract Bronchiectasis is a lung pathology characterized by a permanent dilation of the bronchi and is associated with a chronic coughsputum production and recurrent respiratory infectionsCystic fibrosisCFis one of the best understood inherited conditions that leads to progressive bronchiectasischronic bacterial infection and premature mortalityBoth non CF bronchiectasisNCFBand CF have increased ...

PROJECT SUMMARYZika virusan emerging flavivirusis associated with severe clinical outcomesincluding Guillain Barrsyndrome and birth defectsTransmission of Zika virus is primarily mosquitoborneMosquito salivary proteins are known to enhance infectivity and pathogenesis in Zikadengue and West Nile viruses by modulating immune responsesThis proposal seeks to develop a novel vaccine against Zika virus ...

ABSTRACT This Phase I STTR is designed to evaluate the feasibility of using the OsteoFabtechnology platform for joint arthroplastyArthroFabdevicesspecifically targeting replacement of the small carpal bones in the wrist and hemiarthroplastyOsteoFabtechnology is the combination of Oxford Performance Materialsandaposproprietary formulation of polyetherketoneketoneOXPEKKpolymerand additive manufactur ...

Project Summary Diabetic retinopathy and Retinal Vein OcclusionRVOaccount for most new cases of blindness in the United StatesThese diseases are marked by retinal swellingedemaand new leaky vessel formationneovascularizationtriggered by pathologically high concentrations of Vascular Endothelial Growth FactorVEGFThe primary treatment is VEGF blocking drugs to control the neovascularization and edem ...

PROJECT SUMMARY ABSTRACT Ovarian cancer is the second most common gynecologic cancer in the United States and the most common cause of death among women with gynecologic malignanciesDespite advances in treatment strategiesperitoneal metastasis remains the primary cause of morbidity and mortality in ovarian cancerThe National Cancer Research Institute Clinical and Translational Radiotherapy Researc ...

Project Summary Nerve injury can occur due to traumachronic compression or disease processes such as diabetes or tumors and have a tremendous socioeconomic impact from loss of work and healthcare costsThere is still a clinical need to improve recovery from nerve injuriesand a new nerve conduit drug delivery device that addresses this clinical need is the focus of the present proposalOur group has ...

PROJECT SUMMARY ABSTRACT The opioid fentanyl is administered in millions of procedural sedations every yearIt is very potenthas large interpatient pharmacokinetic variabilityand routinely causes significant respiratory depression if bolused or not titrated judiciouslyDosing and timingcritical for safety and efficacyare presently only possible based on educated guesses and vital signsSedation assoc ...