Award Data

PROJECT SUMMARY Recovery from substance use disorders (SUDs) is greatly impacted by the cognitive and emotional state of the individual, and learning new thought and behavioral patterns can facilitate successful treatment and recovery. Specifically, fluctuations in stress or anxiety can trigger lapses to drug use. Even when actual use is avoided, stress-induced craving is likely to be distracting ...

Project SummaryAbstract We propose to develop aT compact and portable hybrid magnet with high homogeneityandltppmandT of sweep rangeThe magnet system will be used in Overhauser Dynamic Nuclear Polarization experiments in the X Band for studying water dynamics in molecules and other analytical chemistry applicationsIn Phase Iwe will designbuild and test a prototype magnet to meet the above stated r ...

Abstract In the USAlzheimer s diseaseADis the single most expensive diseasethe only disease in the top six for which the number of deaths is increasingThe greatest cost contributors are frequent hospitalizationswhere falls are the largest culpritand frequent need for assistance with the activities of daily livingFall safety systems show the potential to reduce costs and increase quality of care by ...

Abstract SignificanceIn this SBIR projectwe propose to improve the performance of InSighta machine learningbased sepsis screening systemin situations of limited training data from the target clinical siteThe proposed work will make possible prospective clinical deployments to sites which are smaller or lack clinical data repositoriesby significantly reducing the amount of training data necessary d ...

ABSTRACT The goal of this project is to develop a based computer aided diagnosisCADalgorithm for identification of regions at risk for developing esophageal adenocarcinomaEACin optical coherence tomographyOCTscans of the esophagusEAC is one of the deadliest cancers with ayear survival rate of less thanyet the standard of care for detecting precursors to EAC is widely recognized to be inadequateJus ...

Ensuring access to clean water for generations to come will involve developing novel approaches to determining the safety and composition of potable water that are practical and affordableArsenicmercuryand cadmium are three of the top priorities among hazardous substances commonly found at Superfund sitesas they are linked to health problems in people exposed to them in drinking wateryet the curre ...

In the proposed SBIR project Akita Innovations and Adaptive 3D will develop feedstock materials and methods for the additive manufacture of soft elastomers that exhibit resistance to the permeation of chemical agents.The goal of the effort is to produce a fully functional Air Purifying Respirator (APR) and to demonstrate advantages of additive manufacturing to provide innovations such as custom si ...

The objective of the proposed project is evaluation of two novel non aluminum vaccine adjuvantsCpG ODN and AdVaxinulin polysaccharidewith intranasal delivery of thermostable live attenuated influenza vaccineLAIVand irradiation inactivation inactivated influenza vaccineIr IIVpowdersThe proposal aims to formulate thermostable vaccines in the dry powder format using patented Preservation by Vaporizat ...

Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

A majority of U.S. adults own a cell phone and are inclined to use it in emergency situations to call for assistance. Unfortunately, in areas where the density of cell towers is low, such as in rural and off-shore environments, the ability of the wireless network to geolocate the origin of the wireless signal is poor to non-existent. Under the proposed effort, Toyon Research Corporation will devel ...