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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

Displaying 1 - 10 of 6223 results
  1. Analytical Validation of Non-native Transthyretin (NNTTR) As A Candidate Biomarker for Transthyretin Amyloidoses (ATTR)

    SBC: PROTEGO BIOPHARMA, INC.            Topic: NINDS

    Project DescriptionThe transthyretin (TTR) Amyloidoses (ATTR) are progressive fatal diseases caused by the misfolding, aggregation and deposition of mutant and wild-type forms of TTR, a homotetrameric thyroxin transporting protein secreted by the liver, choroid plexus and retina. ATTR presenting as primary polyneuropathy (FAP) can affect the peripheral, autonomic and central nervous systems (CNS). ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Safety and efficacy of an allergy therapeutic targeting FcERI bound IgE in human immune reconstituted mice.

    SBC: Sixal Inc            Topic: NIAID

    PI - Andrew Saxon MD Abstract: The goal of this SBIRI application is to accomplish key “long term” safety and efficacy time-course studies of a novel biologic designed for the preventive treatment of all severe/IgE mediated food allergic reactions and mastocytosis. Allergic diseases and specifically severe food allergies have increased to the point of becoming a major worldwide public health p ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. PAASPort: A web-based tool for nonclinical research quality assessment and risk of bias management to advance development of innovative medications

    SBC: PAASP US, LLC            Topic: NIDA

    PROJECT SUMMARY / ABSTRACTRobust nonclinical data is an absolute requirement for building an effective translational strategy and developing clinically safe and effective medications. Most current efforts to facilitate generation of robust nonclinical research data focus on producing guidelines and checklists pertaining to study design and data analysis, but: a) do so only from a reporting perspec ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. GratePic mHealth App Feasibility Study

    SBC: Gratepic, Inc.            Topic: 600

    PROJECT SUMMARY/ABSTRACT The purpose of this project is to evaluate the effectiveness of GratePic, a mobile health (mHealth) application dedicated to helping users enhance gratitude. A large body of empirical research indicates a strong association between gratitude and psychological well-being, to include: reduction in depressive symptoms, a decrease in suicidal ideations, an increased sense of m ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Temperature-Responsive Clips for Removable Dental Prostheses

    SBC: RODO MEDICAL, INC.            Topic: NIDCR

    ABSTRACT The American Academy of Implant Dentistry reports that about 70% of Americans between the ages of 35-44 have at least one missing tooth, and that one in four over the age of 74 lose all their natural teeth. The first choice treatment for patients with multiple or all of their teeth missing are overdentures, which are removable replacement teeth retained by dental implants. The main reason ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Mucosal Nanoemulsion-Adjuvanted RSV Vaccine using Recombinant Pre-Fusion F Protein

    SBC: Bluewillow Biologics, Inc.            Topic: NIAID

    ABSTRACTRespiratory syncytial virus (RSV) is extremely ubiquitous, with almost all humans acquiring the infection by the age of two.It is manifested by several secondary acute respiratory illnesses including bronchiolitis croup, bronchitis, pneumonia and the common cold.RSV does not elicit a protective immune response in humans, which results in recurrent infections in children and adults.Infants ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted Gene Insertion by Directed Evolution of ΦC31 Integrase for Therapeutic Gene Editing

    SBC: Applied Stemcell, Inc.            Topic: 400

    Pain Point: Applied StemCell (ASC) is engineering ΦC31 integrase through directed evolution to establish the ability to site-specifically integrate exogenous DNA into the human genome. Currently, there are no gene editing technologies on the market that allow for efficient, site-specific insertion of large transgenes. CRISPR/Cas9, and other nuclease-based technologies – including TALENs and Zin ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Targeted Exosome-Associated AAV-Mediated Gene Therapy to Eliminate Metastatic Neuroendocrine Cancers

    SBC: Technology Commercialization Partners LLC            Topic: 102

    ABSTRACT Neuroendocrine (NE) malignancies are hormone secreting neoplasms that arise from endocrine and nervous system. Multiple NE tumors (NETs) have been diagnosed, such as pancreatic neuroendocrine cancers, medullary thyroid cancers, and pulmonary neuroendocrine carcinoids. Most NE cancer patients are metastatic at the time of initial diagnosis which makes the complete resections via surgery im ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Discovery and Development of Broad-spectrum Protease Inhibitors of Flaviviruses of Significant Public Health Threats

    SBC: Plex Pharmaceuticals, Inc.            Topic: NIAID

    Project SummaryMosquito-borne members of the Flavivirus family including Zika virus (ZKV), Dengue virus (DNV) and West Nile virus (WNV), are classified as re-emerging pathogens due to the frequency and severity of recent epidemics. Also known as arboviruses, these viruses are the etiologic agents of many debilitating diseases affecting the human population worldwide. Consequently, vector borne dis ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. New infusible ECM hydrogel for treating acute myocardial infarction

    SBC: VENTRIX INCORPORATED            Topic: NHLBI

    Summary Heart failure post-myocardial infarction (MI) continues to be the leading cause of death in the U.S. Each year it is estimated that ~550K Americans will have a new MI, and ~200K will have a recurrent MI and a majority of these patients will suffer from heart failure. These staggering statistics necessitate the development of new therapies for patients with ischemic cardiomyopathy. Tissue e ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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