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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. "A molecular signature of cell invasion in breast ca.

    SBC: DETROIT R & D, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objective of this research project is to unveil the molecular signature of tumor cell invasion. Tumor invasion and metastasis are complex processes involving extracellular matrix (ECM) degrading proteinase activity and cell migration through the ECMs. Since mounting evidence suggests that ras expression serves as a marker for tumor aggressiveness ...

    STTR Phase I 2004 Department of Health and Human Services
  2. "Extra Innings”: Using Serious Gaming and the Science of Baseball to Teach Science and Mathematics

    SBC: DFUSION INC.            Topic: 999

    DESCRIPTION provided by applicant Due to the rapid advances in science technology engineering and mathematics STEM the United States has been at the forefront of innovation and technology development in the science health and biomedical fields However these continuing advances are in jeopardy as there is a growing national shortage of trained STEM workers While the need for a STEM li ...

    STTR Phase I 2016 Department of Health and Human Services
  3. 12-Lipoxygenase as a Target for Radiosensitization

    SBC: Biomide Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The arachidonic acid (AA) lipoxygenase pathway plays an important role in tumor progression through regulating cell survival, proliferation, and angiogenesis. Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of male death in the United States. During PCa progression, it is found that the expression of 12-lipoxygenase ...

    STTR Phase I 2005 Department of Health and Human Services
  4. 3D Telestration for Robotically Assisted Surgery

    SBC: INTUITIVE SURGICAL            Topic: N/A

    DESCRIPTION (provided by applicant): The speed with which an innovative and improved surgical procedure can be widely adopted is governed principally by the availability of competent surgeon mentors. With its difficult learning curve, minimally invasive surgery has an especially strong need for mentors. Several investigators have developed "telestration," the ability for a remote surgeon mentor ...

    STTR Phase I 2004 Department of Health and Human Services
  5. A 3-D Interactive Atlas of the Human Skull

    SBC: BROWN AND HERBRANSON IMAGING            Topic: N/A

    DESCRIPTION (provided by applicant): Broad long term objectives and specific aims: The long-term objective of this project is to develop a digital anatomical research resource library of very high-resolution computational models, and imaging data sets. Our objective is to produce an anatomical library otf the complete human skeleton. The implications of this project, both scientific and social are ...

    STTR Phase I 2006 Department of Health and Human Services
  6. A Cancer Vaccine for Ovarian and Breast Cancer

    SBC: EPIMMUNE, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this STTR program is to develop an effective cancer vaccine based on class II T cell epitopes derived from four tumor-associated antigens (TAAs) that are commonly over-expressed in ovary-and breast-derived tumors. The role of CD4+ T cell in eliciting an anti-tumor response is critical. The development of tumor specific CTL and the ge ...

    STTR Phase I 2004 Department of Health and Human Services
  7. A Clinical 3D Movement Analysis System for Assessing Lower Extremity Injury Risk and Recovery in Athletes

    SBC: BIONIKS            Topic: NIAMS

    DESCRIPTION provided by applicant The mission of Bioniks is to develop and commercialize accurate low cost movement analysis systems for clinicians ergonomists athletic trainers and other professionals interested in quantifying human movement Our initial focus is on developing computer enhancements for inexpensive D cameras like the Microsoft Kinect These enhancements surpass the accura ...

    STTR Phase I 2016 Department of Health and Human Services
  8. A Genetic Test for Drug-Induced Dyskinesia Risk

    SBC: KOVOGEN            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to develop a genetic test, involving the protein, RGS9, to identify patients that are at risk for developing tardive dyskinesia (TD) or L-DOPA induced dyskinesia (LID). Antipsychotic drugs have revolutionized the treatment of schizophrenia and psychotic disorders but a debilitating side-effect of "typical" antipsychotics is TD, ...

    STTR Phase I 2006 Department of Health and Human Services
  9. A high-throughput kit for detection of RNA modifications

    SBC: MAVERIX BIOMICS, INC.            Topic: NIDA

    DESCRIPTION provided by applicant The broad objective of this project is to develop an integrated wet lab dry lab kit for high throughput detection of RNA modifications The final product will provide all required molecular biology reagents a set of simple and robust experimental manipulations for facile analysis of modifications and researcher friendly analytic cloud based software requi ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A hormonal therapy for preeclampsia

    SBC: ADEPTHERA, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Preeclampsia is a pregnancy specific hypertensive disorder that can lead to multi organ failure seizure and maternal death Preeclampsia is also responsible for as many as of premature births in the United States Although better neonatal care has improved the likelihood of preterm babies surviving many face increased mortality and serious long term mor ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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