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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Identification of Anti-HIV Lead Compounds Targeting Rev
SBC: ADVANCED GENETIC SYSTEMS, INC. Topic: N/ADESCRIPTION (provided by applicant): There is a significant need for novel HIV therapies given the emergence of viruses resistant to existing drug regimens. The Rev-RRE protein-RNA interaction in HIV plays an essential role in the transport of viral mRNA from the nucleus to the cytoplasm where it can be translated or packaged. In preliminary work, two distinct assays targeting the HIV Rev protein ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
Development of Lysosomal Modulatory Drugs to Treat Alzheimer's Disease
SBC: SYNAPTIC DYNAMICS, INC. Topic: N/ADESCRIPTION (provided by applicant): Reducing protein deposition events is essential for slowing the progression of Alzheimer's disease (AD), especially A 1-42 peptide oligomers that accumulate inside and outside neurons and cause functional compromise. Finding a strategy to reduce A oligomeric assemblies is widely thought to be the key objective for treating AD. Accumulation of A peptides is on ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
Multifunctional Carriers for Systemic siRNA Delivery
SBC: SURFAGEN, INC. Topic: N/ADESCRIPTION (provided by applicant): The objectives of this research project are to design and develop safe and efficient multifunctional delivery systems for systemic and target-specific delivery of small interfering RNA (siRNA) to treat human diseases with RNA interference (RNAi). RNAi is a natural mechanism for gene silencing and has a great potential to treat human disease by turning off speci ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
Development of a Health Policy Tool for Prioritizing Health Disparities Targets
SBC: CPM SYSTEMS, INC. Topic: N/ADESCRIPTION (provided by applicant): Eliminating racial disparities in health is a top priority public health goal. African Americans have worse health outcomes and receive worse quality of care for a wide range of diseases, but addressing all of these various disparities in health and health care is not feasible. Instead, we must make judicious use of limited resources and target those aspects of ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
SciVee Pubcasts- New Modes of Scientific Dissemination
SBC: SCIVEE, INC. Topic: N/ADESCRIPTION (provided by applicant): SciVee Inc.'s major product is a Web 2.0 resource that can be found as http://www.scivee.tv and is a YouTube for scientists but much more, as will be outlined subsequently. SciVee represents a potentially exciting and significant enhancement in scholarly communication. SciVee aggregates multimedia content (video, podcasts, text and figures) on topics of scienti ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
Aptamer-based Glycomics Tools
SBC: ECHELON BIOSCIENCES, INC. Topic: N/ADESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is of tremendous importance to the field of glycomics. In this application, we propose to develop a nove ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
A Novel Method for Signaling Pathway Analysis
SBC: ADVAITA CORP Topic: N/ADESCRIPTION (provided by applicant): A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions on various regulatory pathways. Currently, a statistical approach is universally used to identify the most relevant pathways in a given experiment. This approach only considers the set of genes present on each pathway ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
A chemoenzymatic technology for the efficient synthesis of novel cryptophycins
SBC: ALLUVIUM BIOSCIENCES, INC. Topic: N/ADESCRIPTION (provided by applicant): The cryptophycins are a structurally diverse class of polyketide/non-ribosomal peptide natural products that possess potent anticancer activity. However, despite this impressive activity, the development of the cryptophycins into a beneficial cancer chemotherapeutic agent has suffered from clinically significant neurotoxicity that correlates with treatment. Non ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
PPAR-sparing/free Thiazolidinediones for Treatment of Diabetes
SBC: Metabolic Solutions Development Company, LLC Topic: N/ADESCRIPTION (provided by applicant): The overall objective of our proposed research is to discover a PPARg-free thiazolidinedione (TZD) which shows antidiabetic activity in a rodent model of Type 2 diabetes and demonstrates the necessary drug-like qualities to become a clinical candidate for human therapeutics. The insulin sensitizing agents of the TZD class are conventionally thought to operate t ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health -
Evaluation of PPARgam-sparing TZDs for Treating Non-Alcoholic Fatty Liver Disease
SBC: Metabolic Solutions Development Company, LLC Topic: N/ADESCRIPTION (provided by applicant): The overall objective of the proposed research is to discover a PPAR?-sparing thiazolidinedione (TZD) which displays efficacy in a rodent model of non-alcoholic fatty liver disease (NAFLD) and demonstrates the necessary drug-like qualities to become a potential clinical candidate for human therapeutics. The TZD class of insulin sensitizing agents are convention ...
STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health