Award Data

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...

The main objective of this STTR Phase I effort is two-fold. First, to develop a robust approach for coupling the flow solver Kestrel with the multidisciplinary software tool AERO Suite in order to enable the physics-based modeling and simulation of the dynamics of Aerodynamics Decelerator Systems (ADS) such as parachutes from deployment to terminal velocity or terminal descent and touchdown, and t ...

On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...

Traditional approaches to accelerated fatigue testing rely on heuristic methods with thresholds based mostly on experience and engineering judgment. These methods generally do not apply to the multiaxial dynamic loading situations characteristic of most aerospace applications and often result in uncharacteristic fatigue damage and failure modes during testing. To overcome the limitations of tradit ...

In this project, Citrine Informatics and the ADAPT Center at the Colorado School of Mines propose to build an informatics-driven system to understand the effects of defects in additive manufactured parts. The entire history of each sample will be captured on this system; from specific printing parameters and details of precursor materials through to part characterizations and performance measureme ...

The objective of this program is to develop, demonstrate and implement a low reconfigurable, reliable Free Space Optical (FSO) link supporting high bandwidth communications for satellite to satellite or satellite to ground communication. The FSO Transceiver (Transmitter/Receiver) to be implemented will be small Size, Weight, Power and Cost (SWaP-C) such that it can be easily carried by compact spa ...

Qualtech Systems, Inc. (QSI), in collaboration with VU proposes to develop a state-of-the art HMS system featuring: (1) Low Hardware cost by leveraging industrial-grade computers ruggedized to military specifications (2) Low Software cost by leveraging QSI’s COTS TEAMS software with real-time monitoring and diagnosis capabilities (3) Vibration and Shock Analysis and its impact on vehicle and cre ...

The Biomagnetics Micro Dosimetry System (BMDS) program will design, model, and simulate a microdosimetry system that can measure and create a three dimensional map of weak radiofrequency signals in biological organisms. The heart of the BMDS project is the front end called a Quinc, that delivers very sensitive, broad band measurements with high spatial resolution.The Quinc based front end is a val ...