Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Whole Ovary Vitrification for Fertility Preservation

    SBC: 21st Century Medicine, Inc.            Topic: NICHD

    The long term goal of this proposal is to develop a safeeffective and user friendly vitrification system for cryopreservation of whole human ovariesIn the U Sovergirls and women ageare diagnosed with cancer annuallyWhile improved diagnosis and treatment have led to increased survival ratesin premenopausal andin childhood cancer patientsdevastating side effects of cancer therapies include premature ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Smart Entry Needle System for Peritoneal Access and Insufflation during Laparoscopic Surgery

    SBC: Theranova LLC            Topic: NICHD

    AbstractIn themillion laparoscopic surgeries performed annually worldwideachieving peritoneal access for insufflation accounts for one third of the associated complicationsPeritoneal access is typically achieved using the Veress needleHoweverthe use of the Veress needle has been identified as the source ofof the complications associated with laparoscopic proceduresIt has been shown that complicati ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Ninja Theranostics for overcoming the drug delivery barriers to pediatric brain tumor

    SBC: THERANOSTEC INC            Topic: NICHD

    Ninja Theranostics for overcoming the drug delivery barriers to pediatric brain tumor Project Summary Abstract Pediatric brain tumorsPBTsare the leading cause of cancer related morbidity and mortality among childrenVincristineVCRhas been approved to treat PBTsbut its inability to cross blood brain barrierBBBblood brain tumor barriersBBTBand dose limiting neuropathy have greatly limited its clinica ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. A Noninvasive Platform to Assess Maternal Risk for Perinatal Complications in the First Trimester

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. SkillTalk: Communication Training around Sexual Health Topics for Parents of Youth with Autism Spectrum Disorder

    SBC: DFUSION INC.            Topic: NICHD

    ABSTRACT SkillTalkCommunication Training around Sexual Health Topics for Parents of Youth with Autism Spectrum Disorder Adolescents with Autism Spectrum DisorderASDface a range of impairments in social interaction and communication settingsincluding those involved with sexual communication and behaviorLike their neurotypical peersadolescents with ASD need comprehensive sexual education to learn an ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC, INC.            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Senescence After Growth Arrest a new therapeutic modality for progeria

    SBC: Atropos Therapeutics, Inc.            Topic: NIA

    Abstract The long term goal of Atropos Therapeutics Incis development of a therapeutic drug for progeria and other aging related disorders based on their ability to regulate the senescence processAt the end of PhaseSBIRwe anticipate having two to five scaffolds that have utility slowing or preventing cellular senescence in tissue cultureIn phasewe anticipate moving scaffolds toward lead selectiont ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Next generation in vivo miniature microscopes integrating dual-color imaging, 3D imaging, and optogenetic stimulation with a cloud-compatible data acquisition platform

    SBC: Inscopix, Inc.            Topic: 101

    Project Summary Our understanding of neuropsychiatric disorders is undergoing a paradigm shift away from simple models emphasizing neurotransmitter imbalance towards more sophisticated theories based on abnormalities in neural circuit functionThis is especially important for understanding disorders like Schizophrenia and PTSDwhich defy simple biochemical explanationsbut are now known to involve ab ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Novel Transurethral Cryotherapy Catheter System to Treat Benign Prostate Hyperplasia

    SBC: Theranova LLC            Topic: R

    Abstract Benign prostate hyperplasiaBPHis a chronic and highly prevalent medical condition in aging menApproximatelyof men agedyears are affected by BPH and associated lower urinary tract symptomsLUTSa progressive and chronic medical condition that drastically impairs quality of lifeWhile first line drug therapies successfully impede further enlargement of the prostate glandthey only provide modes ...

    SBIR Phase I 2018 Department of Health and Human Services
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