Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: NIMH

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn

    SBC: MicroCures Inc.            Topic: NEI

    The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: ZETROZ SYSTEMS, LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Discovering GIRK Channel Direct Activator as a Novel Chronic Insomnia Therapeutic

    SBC: AFASCI, INC.            Topic: NHLBI

    PROJECT SUMMARY Millions of Americans suffer from sleep disturbances among which insomnia is the most commonInsomnia is often poorly treated with current pharmacotherapies and we propose to develop a new sleep promoting therapeutic based on selective and direct activation of the G protein gated inward rectifier KchannelsGIRKGIRK channels in the brainpredominantly GIRKplay a key role in controlling ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. O-Glycan-dependent Immunotherapy for Cancer

    SBC: GlyTR Therapeutics, Inc.            Topic: 102

    Abstract For decadesthe treatment of cancer has relied on surgical resectionchemotherapy and or radiotherapyRecentlya number of immune based therapies have provided promising new approaches for cancer treatmentThe two most potent immunotherapies are monoclonal antibodymABbased bi specific proteinseg Bispecific T cell engagersBiTEand engineered Chimeric Antigen Receptor T cellsCAR TBoth act by indu ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. An innovative WGS platform for discovery, annotation, and interpretation of all forms of human genetic variation.

    SBC: Base2 Genomics LLC            Topic: 172

    PROJECT SUMMARY Modern DNA sequencing technologies have transformed our ability to interrogate human genomes in a single experimentthereby eliminating the inherent blind spots of gene panels and whole exome sequencingFurthermorerecent speed and economy improvements are driving the cost of whole genome sequencingWGSdown to that of WESthereforewe foresee a transition over the next two years to WGS a ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. TempO-Seq Profiling of RNA Epitranscriptomic Modifications

    SBC: BioSpyder Technologies, Inc.            Topic: 172

    This Fast Track Phase I II SBIR addresses the NHGRI Special Interest Topic CGenomics tools ranging from new instruments to sophisticated molecular biology kitsThe recent discoveries of methylomes of reversibly methylated mRNA and early indications of the functional role these play in cellular function and diseaseand the introduction of RNA immunoprecipitation sequencingRIP Seqderived approaches as ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluation of IPW-5371, a TGFbRI kinase inhibitor, dosed as a single agent or in combination with G-CSF, as a medical countermeasure against the delayed effects of total body irradiation in mice

    SBC: INNOVATION PATHWAYS, LLC            Topic: NIAID

    Abstract Ionizing radiationIRexposure has deleterious effects on multiple organ systems and can be lethal both acutely and later due to the delayed effectsIn the event of a deliberate radiation attack or accidental exposure to radiationa countermeasure can be used to treat exposed populations and prevent death and disabilityNo agent has been approved by the FDA to treat the delayed effects of acut ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Hybrid DNN-based Transfer Learning and CNN-based Supervised Learning for Object Recognition in Multi-modal Infrared Imagery

    SBC: TOYON RESEARCH CORPORATION            Topic: 1

    On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...

    STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency
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