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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Improved Amputee Quality of Life Enabled by Tailored, Self-Regenerating Energy Storage Device For Powered Prosthetics

    SBC: Giner, Inc.            Topic: NICHD

    PROJECT SUMMARY Improved Amputee Quality of Life Enabled by TailoredSelf Regenerating Energy Storage Device forPowered Prosthetics Poweredmotorized prosthetics enable users to more naturally perform taskssuch as climbing stairs or rising from a seated positionHowever because the power requirements fluctuate during the gait cyclethe current battery system is not energy efficient and also since ener ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Noninvasive Platform to Assess Maternal Risk for Perinatal Complications in the First Trimester

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. An oral ROCK2-selective inhibitor for treatment of chronic spinal cord injury

    SBC: BIOAXONE BIOSCIENCES, INC.            Topic: 103

    Roughlypeople in the United States will suffer a spinal cord injurySCIthis yearFor the vast majority of themthe injury will leave them incapable of walking orif they have suffered a cervical SCIentirely dependent upon others for assistance in all of their activities of daily living from feeding to personal careMore importantlychances of improvement as a result of therapeutic interventions are blea ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Preclinical development of AST-004 for astrocyte-mediated treatment of TBI.

    SBC: ASTROCYTE PHARMACEUTICALS INC.            Topic: 103

    PROJECT SUMMARY Traumatic brain injuriesTBIincluding concussionsare an area of significant unmet need with no approved therapeutics and a national burden of$billion annuallyTBI is the global leading cause of post injury death and disabilityand overmillion Americans sustain a TBI each yearThe tremendous incidence and long term consequences of TBI highlight the considerable epidemic at handand the n ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC, INC.            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Conduction cooled superconducting magnet for low cost, compact proton therapy systems

    SBC: Solid Material Solutions, LLC            Topic: NIBIB

    Superconducting magnets are required that enable large borehigher field magnets to be reduced in sizeweightcost and with improved cooling in medical equipment and systems applicationsHigh Temperature SuperconductorsHTSprovide the best options for advancing these systems to higher fields and operating temperatures that are attained with Liquid Heliumfree refrigerationprovided they can be made with ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. PostureCheck: A vision-based compensatory-posture-detection tool to enhance performance of the BURT upper-extremity stroke-therapy device

    SBC: Barrett Technology, LLC            Topic: NIBIB

    SummaryAbstractThis Small Business Innovation ResearchSBIRPhase I project proposes the development of an imageprocessing based toolnamed PostureCheckaimed at automatically detecting when patients perform undesirable compensatory movements during robot assisted upper limb rehabilitation exercisesThe system will be based on a standard video camerae gGoProthat will be used to capture the movements of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Droplette: A Platform Technology for At-Home, Effective, and Rapid Pulmonary Delivery to Reduce Ventilator Use and Hospitalization

    SBC: NOVOPYXIS INC.            Topic: NIBIB

    Significance: COVID-19 causes significant lung damage in a subset of patients leading to a cascade of inflammatory cytokine activation (cytokine storm) that develops into acute respiratory distress syndrome (ARDS). There are several classes of FDA-approved therapeutics that have significant potential in mitigating the pulmonary inflammation when effectively delivered into the lower airways. Howeve ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. First-in-human study of MW151, a novel drug targeting neuroinflammation

    SBC: ImmunoChem Therapeutics, LLC            Topic: NIA

    ABSTRACT Alzheimerandapos s diseaseADis one of the largest global public health crises facing us todayyet there are no effective therapies available to preventdelayor slow AD progressionDominant approaches based on a set of prevailing core hypotheses about druggable pathways and targets have failedThereforethere is a need for novel and alternative pathways distinct from those pursued over the past ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Managing Vascular Dementia Risk Factors with SymTrend

    SBC: SymTrend inc            Topic: NIA

    Project Summary AbstractAbstractDiseases of blood vessels in the brain culminate in vascular dementiaVaDand ultimately rob one of independence in activities of daily living in elder yearsThey often commence an insidious progression in early to midlife with a concomitant diminution in work proficiencyVascular dementia is treatablehoweverSuccessful containment of the progression requires rigorous ma ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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