Award Data

PROJECT SUMMARY Improved Amputee Quality of Life Enabled by TailoredSelf Regenerating Energy Storage Device forPowered Prosthetics Poweredmotorized prosthetics enable users to more naturally perform taskssuch as climbing stairs or rising from a seated positionHowever because the power requirements fluctuate during the gait cyclethe current battery system is not energy efficient and also since ener ...

Project Abstract Adolescents can benefit greatly from evidence basedmedically accurate sexual and relationship health educationHoweverboth teachers and parents face challenges in effectively teaching about sexual health and relationships leading to students receiving incomplete or inaccurate informationYoung people turn to the media for informationand many media messages about sex and relationship ...

Kabuki SyndromeKSis a congenital multisystemic disorder hallmarked by distinctive facial featuresshort statureintellectual disabilityrecurrent infection hearing impairment and organ malformationsPatients require complex clinical managementand treatment options are limitedHuman genetics studies have illuminated the pathobiology of KSwith mutations in two methyltransferasesKMT D and KDM Aaccounting ...

Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

Roughlypeople in the United States will suffer a spinal cord injurySCIthis yearFor the vast majority of themthe injury will leave them incapable of walking orif they have suffered a cervical SCIentirely dependent upon others for assistance in all of their activities of daily living from feeding to personal careMore importantlychances of improvement as a result of therapeutic interventions are blea ...

PROJECT SUMMARY Traumatic brain injuriesTBIincluding concussionsare an area of significant unmet need with no approved therapeutics and a national burden of$billion annuallyTBI is the global leading cause of post injury death and disabilityand overmillion Americans sustain a TBI each yearThe tremendous incidence and long term consequences of TBI highlight the considerable epidemic at handand the n ...

AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

Project Summary Autism Spectrum DisorderASDis a broad diagnosis for a disorder characterized by symptoms affecting repetitive behaviorsocial communicationand cognitive abilityinchildren in the US is affected with ASDCenters for Disease Control and Preventionand the likelihood that a child will be affected with ASD istimes higher if they have a sibling with ASDTraditionallydiagnosis occurs most fre ...

Acne Vulgaris is a common skin disorder that affectsof the populationtypically teenagers and young adultsOvermillion people in the US are affected by acne generating a $billion market for acne treatmentsof which is derived from prescription medicationsAlthough acne is not a life threatening conditionit still has a high psychosocial impact resulting in depressionanxietyangersuicidal thoughtsphysica ...

Superconducting magnets are required that enable large borehigher field magnets to be reduced in sizeweightcost and with improved cooling in medical equipment and systems applicationsHigh Temperature SuperconductorsHTSprovide the best options for advancing these systems to higher fields and operating temperatures that are attained with Liquid Heliumfree refrigerationprovided they can be made with ...