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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. A Noninvasive Platform to Assess Maternal Risk for Perinatal Complications in the First Trimester

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    Limited information is available about early human placentation when many pregnancy pathologies originateTo address this knowledge gap and begin development of robust diagnostic tool to manage pregnancy complicationswe propose a pilot study based on a highly sensitive immune assay and our company s base technologyTrophoblast Retrieval and Isolation from the CervixTRICTRIC uses a Pap smearconsidere ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A therapeutic approach for potential prevention of aromatase inhibitor-induced bone loss

    SBC: NANOMEDIC, INC.            Topic: NIA

    AbstractIn this SBIR Phase I applicationour goal is to demonstrate proof of concept of our lead chelating agent as a potential therapeutic for the prevention of osteoporosis induced by aromatase inhibitorAItherapy in postmenopausal women with hormone receptor positive breast cancerAlthough AI therapy shows great improvements in cancer free and overall survivalits treated patients face a risk of os ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: NIMH

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Automated Real-Time Trauma Resuscitation Communication System for Clinical Decision Support

    SBC: Lifeboard Medical            Topic: NLM

    PROJECT SUMMARY Despite rapid transport to appropriate facilitiesmany trauma patients needlessly die in the first hour of careTrauma is the leading cause of death for Americans under the age ofand greatest cause of potential life years lost before the age ofexceeding that of either cancer or heart diseaseUp toof traumatic deaths may be preventableIt is estimated that miscommunication is the leadin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. VGo-Assist, A Mobile Telepresence Robot to Engage Persons with Alzheimer's Disease and Related Dementias

    SBC: Vecna Technologies, Inc.            Topic: NIA

    PROJECT SUMMARY ABSTRACTThis project s long term purpose is to adapt an existing telepresence robotVecna s VGofor remote care of persons living at home with early stage Alzheimer s and related dementiasADRDIt responds to the NIA s call for development of robots to support care management and independent livingpromote social engagementreduce lonelinessand assist family members and professionals in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. User-driven Retrospectively Supervised Classification Updating (RESCU) systemfor robust upper limb prosthesis control

    SBC: Infinite Biomedical Technologies, LLC            Topic: NINDS

    ABSTRACT Approximately individuals live with upper limb loss loss of at least one hand in the US Fortunately prosthetic devices have advanced considerably in the past decades with the development of dexterous anthropomorphic hands However potentially the most promising used control strategy myoelectric control lacks a correspondingly high level of performance and hence the use of dexterous hands r ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Development and Evaluation of Computerized Olfactory Training Program (COT) for Cognitive Decline in Preclinical and Early Alzheimer's Disease (AD)

    SBC: EVON MEDICS, LLC            Topic: NIA

    ABSTRACT The Development and Evaluation of Computerized Olfactory Training ProgramCOTfor Cognitive Decline in Preclinical and Early Alzheimer s DiseaseADis a project to develop a home based brain stimulation device for prevention of AD progression in preclinical and early ADThe success of enriched odor environment for reversal of AD pathology in animals spurred high hopes for translation of olfact ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of CDK5-p25 modulator to treat Alzheimer's Disease and Frontotemporal Dementia

    SBC: Cogentis Therapeutics, Inc            Topic: NIA

    Post-mortem evidence shows that CDK5, a major kinase for tau and amyloid precursor protein, is hyperactive in the brains of patients with AD. Multiple genome wide association studies link CDK5 alleles to AD. Elegant genetic mouse(5xFAD) and human stem cell-derived neuron studies demonstrate the CDK5 hyperactivity is required (rather than just a correlation) for progression of AD pathology. CDK5 is ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: Zetroz Systems LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Reformulated Hypertension Pharmaceuticals for Treatment of Diabetic Foot Ulcers

    SBC: GEMSTONE BIOTHERAPEUTICS, LLC            Topic: 200

    Chronic wounds are deficient in the normal mechanisms that regulate healingand dysregulation of these signaling pathways leads to skin breakdown and poor wound healingMost new wound treatments have not targeted this underlying biochemistrybut have instead focused on treating infection and debridementThe renin angiotensin systemRASis active in connective tissue and skin and has a known role in woun ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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