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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Extended half-life GlyTR1 combined with checkpoint blockade for Cancer Immunotherapy

    SBC: GLYTR THERAPEUTICS, INC.            Topic: 102

    AbstractTreatment of non-resectable recurrent/metastatic solid cancers is currently palliative only and there is an urgent unmet need for novel mechanisms of action and additional paradigm shifting therapeutic options. Antigen- targeting cancer immunotherapies such as bi-specific antibodies (eg Bi-specific T cell engager or BiTE’s) provide a unique approach for cancer immunotherapy. However, app ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Chondrofluid for arthroscopic knee cartilage repair

    SBC: CARTILAGE INC            Topic: NIAMS

    PROJECT SUMMARY Minor injuries to articular cartilage can initiate a catabolic cascade, causing small defects to progress into larger, more symptomatic defects. Pain, lesion progression, and accelerated joint deterioration may be avoided with strategies that repair small defects with hyaline-like cartilage. The repair of chondral defects using arthroscopic techniques, performed in a minimally inva ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced optics to unlock large field-of-view multiphoton imaging for neuroscience and beyond

    SBC: PACIFICOPTICA LLC            Topic: 101

    Project summary Currently available optical components limit biomedical imaging. In particular, in neurobiology, standard microscope components limit the field-of-view and speed of imaging of neuronal activity. Through prior work on BRAIN Initiative project, we have developed approaches for new optical components that expand the field-of-view 5 to 50 times over standard microscopes, with no loss i ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Crohn's disease

    SBC: TRIANGLE THERAPEUTICS INC.            Topic: 300

    PROJECT SUMMARY Crohn’s disease (CD) is a chronic autoimmune disease in which cells of the immune system attack gut tissue leading to diarrhea, fatigue, pain, and weight loss. CD affects up to one million Americans and is a type of inflammatory bowel disease. CD is driven by CD4 T cells with a significant role for TH1 and TH17 cells and additional involvement of B cells. Current therapies for CD ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Demonstrating miniaturized production of a KOR PET tracer as a proof-of-concept for low-cost distribution of nascent PET neurotracers

    SBC: DropletPharm Inc.            Topic: NIDA

    PROJECT SUMMARY / ABSTRACT Positron-emission tomography (PET) studies play a critical role in many areas of neurological health by enabling quantitative in vivo measurements of specific neuroreceptor systems (e.g. receptor density, drug occupancy, endogenous ligand occupancy) to (i) evaluate fundamental hypotheses about disease or (ii) aid in the development of novel treatments targeting those rec ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Evaluation of recombinant bovine lactoferrin and N-linked glycan effects on infant gut health and immunity

    SBC: TURTLETREE LABS INC.            Topic: NICHD

    Project Summary/Abstract Most infants currently rely on infant formula (IF) to meet their nutritional needs. However, existing infant formula is functionally inferior because it lacks breast milk bioactive proteins that are crucial to infant health and development. Consequently, formula-fed infants have increased risk of morbidity and mortality. Current technology limits the ability to add bioacti ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Live spike sorting for multichannel and high-channel recordings

    SBC: POPNEURON LLC            Topic: 106

    Project Summary: The goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes. In most in-vivo extracellular recording conditions, an electrode can pick up neural spikes from several nearby neurons resulting in so-called “multi ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Deep Reinforcement Learning for Collaborative Multi-Robot Systems with Low-Latency Wireless Networking

    SBC: TIAMI LLC            Topic: N23BT031

    In this Phase I effort, Tiami, LLC, aims to develop and demonstrate a hardware proof of concept for a collaborative multi-robot system (MRS) that leverages imitative augmented deep reinforcement learning (IADRL) amongst heterogeneous uncrewed systems (robots) to achieve a common task. Collaboration is based on low-latency machine-to-machine wireless links between robots that use both RF and optica ...

    STTR Phase I 2023 Department of DefenseNavy
  9. Ad Hoc Swarm Modulation and Adaptation

    SBC: IOTAI INC            Topic: N23BT031

    Ad Hoc Swarm Modulation and Adaptation focuses on the ability to enable secure cyber communications, data, and distributed AI processing for any robotic swarm in any condition.  The system incorporates a range of multi-robotic system functionality to allow for coordination, cooperation, and reconfigurable methods of robotic teams, flocks, and swarms.  The system further includes methods for swar ...

    STTR Phase I 2023 Department of DefenseNavy
  10. Targeting TLR4-lipid rafts to prevent postoperative pain

    SBC: RAFT PHARMACEUTICALS LLC            Topic: 108

    PROJECT SUMMARY Postoperative pain is a prevalent source of pain requiring appropriate management to reduce its impact upon quality of life. Even with the availability of several analgesics, postoperative pain is often undermedicated because of concern related to the adverse consequence of the available therapeutics (e.g., NSAIDs and opiates), including addiction and decreased survival of cancer p ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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