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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of Autonomous Glycemic Control Mechanism for Patients Suffering Glycemic Abnormalities as a Result of Critical Illnesses

    SBC: PROFUSA, INC.            Topic: ST18C004

    The use of continuous glucose monitors can be an invaluable management tool for patients afflicted by glycemic variability due to critical illness or trauma. Maintaining stable glucose levels enhances health and lowers care costs, and individuals equipped with continuous glucose data have significantly improved outcomes. Profusa has developed highly miniaturized, injectable, tissue-like, glucose s ...

    STTR Phase I 2019 Department of DefenseDefense Advanced Research Projects Agency
  2. Visual Relative Navigation via Intelligent Ephemeral Relationships (VRNIER)

    SBC: TOYON RESEARCH CORPORATION            Topic: ST18C006

    As unmanned aircraft systems (UAS) become more prevalent there is an increasing desire to automate UAS navigation and control. To enable future UASs to perform a wider variety of missions, the they must be able to complete autonomous relative navigation to accomplish missions. Current technologies rely heavily on GPS measurements, which are undesirable since GPS signals may be unavailable in many ...

    STTR Phase I 2019 Department of DefenseDefense Advanced Research Projects Agency
  3. Pathogen Classification Tool (PaCT)

    SBC: Stottler Henke Associates, Inc.            Topic: ST18C002

    Stottler Henke proposes PaCT, leveraging our related past work in computer vision and machine learning. Drawing from techniques used in ExPATSS, a Phase II SBIR effort slated for transition to the Naval fleet, PaCT will perform bacterial characterization using features derived from the phenotype of the bacteria. PaCT will predict bacterial characteristics such as pathogenicity, antibiotic resistan ...

    STTR Phase I 2019 Department of DefenseDefense Advanced Research Projects Agency
  4. Human Performance Optimization: Ketone Esters for Optimization of Operator Performance in Hypoxia

    SBC: HVMN Inc.            Topic: SOCOM17C001

    In the setting of altitude-induced hypoxia, operator cognitive capacity degrades and can compromise both individual and team performance. This degradation is linked to falling brain energy (ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone bodies are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies have sho ...

    STTR Phase I 2018 Department of DefenseSpecial Operations Command
  5. Marburg Virus Prophylactic Medical Countermeasure

    SBC: MAPP BIOPHARMACEUTICAL, INC.            Topic: CBD18A002

    There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  6. Marburg Virus Prophylactic Medical Countermeasure

    SBC: Flow Pharma, Inc.            Topic: CBD18A002

    Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  7. Computational Biology Platform Technology for Cellular Reprogramming

    SBC: IREPROGRAM, LLC            Topic: ST17C001

    Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...

    STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  8. Complex Networks for Computational Urban Resilience (CONCUR)

    SBC: PERCEPTRONICS SOLUTIONS, INC.            Topic: ST17C003

    CONCUR develops a computational framework for assessing and characterizing urban environments stability or fragility in response to volatility and stress, identifying specific weaknesses as well as key tipping points which could lead to rapid systemic failure. CONCUR explicitly models urban environments as emergent complex systems, focusing attention on the critical triggers that could lead to rap ...

    STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  9. Nonintrusive Detector of Acute Cognitive Strain (DACS)

    SBC: Quantum Applied Science And Research, Inc.            Topic: ST16C003

    Modern defense systems place high cognitive demands on warfighters, often taxing the limit of human capabilities and causing operators to suffer Acute Cognitive Strain (ACS), wherein performance deteriorates markedly, leading to a loss of situational awareness and control, and decrements in team cooperativity. ACS leads to physiological changes driven by sympathetic system activation, including i ...

    STTR Phase I 2017 Department of DefenseDefense Advanced Research Projects Agency
  10. Optimizing Human-Automation Team Workload through a Non-Invasive Detection System

    SBC: Cognionics, Inc.            Topic: ST16C003

    This STTR project aims to assess the feasibility of using laryngeal EMG to detect operator workload and strain. Phase I will develop a wearable neckband device positioning an array of laryngeal EMG electrodes plus additional sensors for measuring masseter EMG, heart rate variability, GSR and estimated relative blood pressure. The neckband will be optimized to be both wearable, comfortable and resi ...

    STTR Phase I 2017 Department of DefenseDefense Advanced Research Projects Agency
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