Award Data

Hematopoiesis, the regulated production of mature blood cells, is a complex scheme of multilineage differentiation which occurs mainly in the bone marrow of adult mammals. Mature cells are continuously produced from progenitor (or precursor) cells. Consequently, assays which detect these progenitor cells are vital in many research and clinical settings. The current assay procedures suffer from a n ...

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Efficient separation and purification of bioproducts on a commercial scale are controlling steps in the bioprocessing of high value-added products such as therapeutics in human health care. This project will examine the feasibility of achieving significant improvement in downstream processing through-put by the use of flow-induced vortices to reduce or eliminate the effect of concentration polariz ...

Preliminary studies have demonstrated the feasibility of a novel computational scheme which will address critical errors in the present methodology of source localization. These studies will also make it feasible to obtain source location and pattern of activity based on realistic models of the head constructed from MRI or CT imaging modalities. Potential clinical applications include functional i ...

The objective of this effort is to demonstrate a prototype advanced diagnostic system for the T800 turboshaft engine using a hybrid polynomial network and production-rule expert system. The resulting system will demonstrate the feasibility of developing a revolutionary diagnostic capability which can model the engine at a system level, detect failures before they become signficant isolate faults, ...

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COMPUTERIZED DATA COLLECTION DEVICES EXIST AND ARE BEING USED IN VARIOUS APPLICATIONS AT SOME NPPS FOR SYSTEMS AND EQUIPMENT NOT INSTRUMENTED IN THE CONTROL ROOM. HOWEVER, CURRENT APPLICATIONS IN THE NUCLEAR POWER INDUSTRY ARE RATHER SPORADIC AND NOT EXPLOITING THE FULL POTENTIAL OF THE TECHNOLOGY. FOR EXAMPLE, SEVERAL DIFFERENT NPPS USE SUCH SYSTEMS FOR SINGLE- PURPOSES SUCH AS TRENDS IN EQUIPMEN ...

THE EFFECTIVENESS OF THE NEUTRAL PARTICLE BEAM (NPB) MISSILE DEFENSE SYSTEM DEPENDS ON THE SUCCESSFUL ACCELERATION OF HIGH BRIGHTNESS H ION BEAMS AT HIGH CURRENTS WITH CONTINOUS WAVE (CW) OPERATION. PRESENT BASELINE DESIGNS FOR THESE POWERFUL LINAC SYSTEMS INCLUDE ONE OR MORE STAGES OF BEAM COMBINATION (FUNNELING) INTO LATER STAGES OF THE LINAC TO OVERCOME THE CURRENT LIMITATIONS OF THE INITIAL LI ...

The primary goal of this Phase I design study is to develop the design of an accelerator-based neutron source for clinical boron neutron capture therapy (BNCT) using the compact radio-frequency quadruple (RFQ) linear accelerator. This accelerator design study will be completed in collaboration with the Brain Tumor Research Center at the University of California in San Francisco (UCSF). The acceler ...

THE USE OF THE RADIO FREQUENCY SUPERCONDUCTING ION LINACS HAS GROWN STEADILY OVER THE PAST 15 YEARS, PRIMARILY FOR APPLICATIONS IN NUCLEAR AND ATOMIC PHYSICS WHERE FLEXIBILITY N ION SPECIES AND ENERGY ARE REQUIRED. THIS TECHNOLOGY CONTINUES TO BE ACTIVELY DEVELOPED AT SEVERAL LABORATORIES WORLDWIDE. A RECENT DEVELOPMENT AT THE ARGONNE TANDEM LINAC ACCELERATOR SYSTEM (ATLAS) FOR THE NEW POSITIVE IO ...