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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)
SBC: SIBTECH, INC. Topic: NCINew therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...
SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Validating the MicroKine Assay for Use in Identifying Personalized Precision Therapies for Pediatric Sepsis
SBC: PreDxion Bio, Inc. Topic: NICHDProject Summary Abstract PreDxion BioLLC is a precision medicine diagnostic company developing an assay platformthe MicroKineassay cartridge and readerthat measures serum proteins in less thanminutes from a single drop of bloodThis fastactionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsisthe number ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
A Noninvasive Prenatal Testing Platform for Aneuploidy at Five Weeks of Gestation
SBC: Cradle Genomics, Inc. Topic: NICHDThe overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detectany inheritable trait as early asand up toweeks of gestationfrom a safenoninvasive Pap smearStudiesshow that perinatal Pap tests pose no risk to mother or fetusand capture trophoblastlike cells that migrate fromtheplacentaintothereproductivetractTrophoblastretrievalandisolationfrom ...
SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Targeting Exonuclease Resistant RNA to Develop Zika Virus Therapeutics
SBC: Nymirum, Inc. Topic: NIAIDProject Summary Abstract Outbreaks of Zika VirusZIKVhave been recorded in Africathe AmericasAsiaand the Pacificand despite significant resources being dedicated to combat ZIKV proliferationthere is no known cureMany mosquitoborne flavivirus such as ZIKVDengue virusYellow Fever virusand West Nile virus have structuredUTRsStructured RNA elements in theUTRs allow the virus to resist degradation by ho ...
SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Antimicrobial Intravascular Catheter Lock Solutions Based on Endogenous Nitric Oxide Release Agent
SBC: NOTA Laboratories, Inc. Topic: NIAID! AbstractIntravascularIVcatheters in the hospital setting are associated with a high rate of bacterial colonizationresulting in andgtdeaths annually in the U Sfrom catheter related blood stream infectionsCR BSIsNewer commercial catheters pre loaded with silver or antibiotics within their walls have failed to dramatically reduce this very significant problemA variety of catheter lock solutionscath ...
SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics
SBC: SAB CAPRA, LLC Topic: NIAIDProject Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
The Kappa Partial Agonist PPL-103 as a Potential Cocaine Abuse Pharmacotherapy
SBC: PHOENIX PHARMALABS, INC. Topic: NIDAAbstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
An antigen-detection assay to diagnose Babesia microti infection
SBC: L2 DIAGNOSTICS LLC Topic: NIAIDProject Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...
SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury
SBC: Mitovation, Inc. Topic: 101Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Embryonic stem cell high throughput screen accurately reports toxic stress
SBC: REPRODUCTIVE STRESS MEASUREMENT MECHANISMS & MANAGEMENT CORP Topic: NIEHSState of the art techniques in Developmental and Reproductive Technology use slowexpensive testing of pregnant female rodentsor of embryonic stem cellsESCsthat are cultured to lose stem cell qualities and differentiate into organ tissuesThis only produces toxicological outcomes similar to those in adult versions of these organsReproductive StressM has established high throughput screensHTSsthat te ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health