Award Data

The drug R&D cycle is long and very expensive. In many ways, this status quo can no longer be sustained. One of the reasons for such great cost is that the vast majority of drug candidates are screened out at the stages of animal and human trials. More efficient methods of testing of drugs at the stage of ex-vivo studies, which are substantially less expensive than animal and human testing cyc ...

To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses in-house developed mature compone ...

Impregnated ASZM-TEDA carbon employed as highly adsorptive materials in Collective Protection (ColPro) systems loses the ability to adsorb toxic chemicals because of exposure to temperature, humidity, battlefield contaminants, and other pollutants. To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of probing the degradation in physical adsorption ...

To address the Chemical/Bio Defense (CBD) need for in vitro models suitable for high-throughput screening of drug toxicities in human tissues, Physical Optics Corporation (POC) proposes to develop a new three-dimensional (3D) Microfluidic Platform for in-vitro Hematopoietic Stem Cell (HSC) Culture (3D-Mic-Stem). This proposed system is based on a 3D microfluidic design that uses HSCs for assaying ...

To address the U.S. Army/DTRA’s CBD program need for a robust screening process for use with large panels of enzymes to identify variants with higher affinity for organophosphorus (OP) substrates, Physical Optics Corporation (POC) proposes to develop a Microfluidic Dielectrophoretic Screening (MDS) system. This proposed system is based on the new design of a microfluidic mixer, enzymatic reactor ...

Alameda Applied Sciences Corporation (AASC) proposes to develop two components of a three-component, survivable debris shield for large area test exposures to cold (1-5keV) x-rays. These elements also have commercial potential in accelerators and in radiography. The elements are: an ultrafast gas curtain designed to be located close to the x-ray source to deflect plasma debris as well as ~um siz ...

"The US Joint Services, Federal Agencies, and state and local First Responders have expressed dissatisfaction with currently employed organophosphate (OP) sensors. They have identified the need for a new generation of sensors that is small, light-weight,and easy to use while being capable of extended operations in rugged environments. Advanced Sensor Technologies proposes to address these issues w ...

Aerius Photonics and partner Ahura Scientific, propose to develop a handheld system, based on Ahura’s successful FirstDefender Raman system, that employs an excitation laser emitting at 980 nm and a low noise InGaAs array based on Aerius’ high performance InGaAs technology. This system will substantially reduce the fluorescence present in CCD-based systems, and unmask otherwise obscured spect ...

The goal of this Phase I SBIR is to define a set of algorithms that will detect and characterize static man-made objects highly obscured by foliage within multi-view, multi-channel optical data collected passively from UAVs or other aerial platforms. The proposed algorithm stream will be constructed so as to comprehend and mitigate real-world interfering effects such as clouds, smoke and haze. Dur ...

Bioren's technology provides an efficient, automated, in vitro system to generate and optimize antibodies and antibody fragments through a rational, hypothesis-driven approach. Bioren's patented technology is based on synthetic oligonucleotide chemistry to create defined antibody mutations. Hypotheses regarding the impact of a specific amino acid's side-chain chemistry within the antigen binding ...