Award Data

DESCRIPTION provided by applicant A range of neurological diseases are now being researched or treated using fully implantable electronic systems to either record or modulate brain activity in humans These implants are currently being protected using polymer coatings that envelop the implant and help keep body fluids away from the sensitive electronics Brain implants with complex three dimens ...

DESCRIPTION provided by applicant Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station Automation of drug administration and on demand dose adjustment in freely moving animals offers greater throughput and improved outcomes compared to existing technologies Towards this end this proposal focus ...

DESCRIPTION provided by applicant Even as the cost and throughput of commercial sequencers has continued to improve over the last years there is still a need to further reduce sequencing costs to increase throughput and sequencing accuracy and to reduce the costs associated with sample preparation Single molecule methods such as the Pacific Biosciences or nanopore technologies have the pot ...

DESCRIPTION provided by applicant Tumor microenvironment TME makes an essential contribution to tumor progression recurrence and metastasis Currently there is no standardized method to quantify major components of TME simultaneously such as lymphovascular invasion and to predict locoregional recurrence and metastasis of cancer The primary goal of this project is to develop a technology ...

DESCRIPTION provided by applicant Since the first procedure in there has been an explosive growth in transcatheter aortic valve replacement TAVR Up to date more than TAVR had been performed worldwide Despite the increased global experience with TAVR severe adverse events associated with TAVR have been extensively documented including annulus rupture coronary occlusion para ...

DESCRIPTION provided by applicant Novel caveolin modulators as therapeutics for uveitis Project Summary This research proposal seeks to develop a novel therapy for uveitis based upon modulation of inflammatory signaling via caveolae Uveitis drives of blindness affecting people of working age and producing significant disability in patients with chronic disease Caveolin modulators such ...

DESCRIPTION provided by applicant In the United States million children and adults have diabetes and million have pre diabetes Insulin therapy is critical in Type Diabetes and now understood to be an inevitable therapeutic component for Type Diabetes in order to achieve adequate glycemic control However none of the available commercial insulin preparations are able to simulate n ...

DESCRIPTION provided by applicant This project addresses the need for better methods for deciphering the glycosylation of proteins in clinical samples Glycosylation is an important modifier of protein structure and function and contributes to disease processes But we currently know little about the glycosylation of most proteins The current methods for probing glycans on proteins are not su ...

DESCRIPTION provided by applicant Like all neurons of the central nervous system CNS retinal ganglion cells fail to regenerate and often die after damage to the optic nerve such as occurs in optic nerve stroke or other optic neuropathies Loss of axonal connectivity and neuronal death that occurs after damage to the optic nerve results in vision loss While therapeutics targeting secondary ...

DESCRIPTION provided by applicant Young people remain disproportionately affected by HIV School based prevention programs such as Reducing the Risk RTR have demonstrated effectiveness in reducing the sexual risk taking behaviors associated with HIV transmission School settings are an important venue for reaching adolescents nationwide with effective prevention education and most states h ...