You are here
Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
-
Histone Deacetylase Inhibitors for Cancer Treatment
SBC: Angiogen, Inc. Topic: N/ADESCRIPTION (provided by applicant): Histone deacetylases (HDACs) comprise a family of enzymes that catalyze the removal of acetyl groups from lysine residues of histones. They mediate chromatin remodeling and gene expression. HDAC inhibitors are potent inducers of growth arrest, differentiation or apoptic cell death and suppress cell proliferation in a variety of transformed cells in culture and ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Amino acid derived urea based chemicals as sEH inhibitor
SBC: Arete Therapeutics, Inc. Topic: N/ADESCRIPTION (provided by applicant): Recent findings indicate that increasing levels of epoxides of arachidonic acid (EETs) appear to be new and excellent means to treat both hypertension and vascular inflammation. We demonstrated that in vivo inhibition of soluble epoxide hydrolase resulted in higher levels of EETs and in reduction of blood pressure and inflammation in animal models. Because the ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Novel epoxide hydrolase inhibitor for stroke prevention
SBC: Arete Therapeutics, Inc. Topic: N/ADESCRIPTION (provided by applicant): A major cause of morbidity and mortality is the progression of organ damage associated with cardiovascular diseases. For instance, the incidence of stroke and costs associated with stroke damage continues to have a devastating impact on public health despite numerous treatments aimed at cardiovascular risk factors. Recent findings indicate that increasing lev ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Quantitation Pulmonary Delivery of Therapeutic Protein
SBC: Arizeke Pharmaceuticals, Inc. Topic: N/ADESCRIPTION (provided by applicant): Arizeke Pharmaceuticals, Inc. is focused on the pulmonary delivery of protein therapeutics (including antibodies) to treat pulmonary disease. Arizeke's technology provides a unique ability to deliver large therapeutic proteins into the lung parenchyma and interstitium and into the lymphatic drainage system. Examples of indications that can be targeted by this t ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Radiosensitization by modulating inhibitors of apoptosis
SBC: Ascenta Therapeutics, Inc. Topic: N/ADESCRIPTION (provided by applicant): Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves anti-apoptotic signal transduction pathways that prevent radiation-induced cell death. The inhibitors of apoptosis proteins (IAP) are important intrinsic cellular inhibitors of apoptosis, highly expressed in prostate and lung cancer cells, and play an important role in resistance ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
AEGIS: A Pixel-array Readout IC for Gamma-ray Imaging
SBC: Augustine Engineering Topic: N/ADESCRIPTION (provided by applicant): CdZnTe arrays are promising detectors for improving nuclear medicine imaging, but existing CdZnTe cameras have limited spatial resolution and small numbers of pixels (space bandwidth product = SpBW). We show that major performance improvements will require high SpBW (>10A5) and small pixels (high resolution). The best approach to obtaining high SpBW detectors i ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
12-Lipoxygenase as a Target for Radiosensitization
SBC: Biomide Corporation Topic: N/ADESCRIPTION (provided by applicant): The arachidonic acid (AA) lipoxygenase pathway plays an important role in tumor progression through regulating cell survival, proliferation, and angiogenesis. Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of male death in the United States. During PCa progression, it is found that the expression of 12-lipoxygenase ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Isotopically Labeled Nucleotides for Biomolecular NMR
SBC: CASSIA, LLC Topic: N/ADESCRIPTION (provided by applicant): The goal of the proposed research is to scale up the production and manufacture of high-value ribonucleoside triphosphates containing stable isotope labels. The use for these products is in biomolecular studies of RNA structure using Nuclear Magnetic Resonance (NMR) spectroscopy. The market for these products is structural biology groups in academic and industr ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
Novel Transcription Profiling in Toxicologic Assays
SBC: Genpathway, Inc. Topic: N/ADESCRIPTION (provided by applicant): A common reason for failure of drugs in development or their removal from the market is hepatotoxicity. This is due to the many adverse drug reactions and drug-drug interactions that result from drug metabolism, enzyme induction or inhibition of drug metabolizing enzymes. Unfortunately, effective in vitro and in vivo approaches to accurately predict hepatotoxi ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health -
CODA Assembly of Mutant Genes
SBC: CODA GENOMICS, LLC Topic: N/ADESCRIPTION (provided by applicant): The opportunity addressed by this proposal is to provide the scientific and medical communities with the ability to perform rapid, inexpensive, and accurate mutation studies of any protein, using a scaffold based on synthetic genes computationally optimized for DNA self assembly and for expression and translation in an in vitro or in vivo system of choice. Cu ...
STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health