Award Data

DESCRIPTION (provided by applicant): This STTR grant proposal is for the development of a safe and efficacious Anthrax Toxin Vaccine. The present world-wide threat of the use of anthrax spores as a bioterrorist weapon in military theaters as well as on the general population has focused attention on the need for a more effective vaccine against anthrax. The recognition during the past few months t ...

DESCRIPTION (provided by applicant): Conventional methods to identify and test the antibiotic susceptibility of Mycobacterium tuberculosis are both slow and insensitive. Current nucleic acid amplification-based techniques present a partial solution by offering a more rapid result, but these methods require a relatively high degree of technical sophistication. Furthermore, assay sensitivity is oft ...

DESCRIPTION Preliminary studies show that there is correlation between a component in saliva and DFT (number of decayed and/or filled teeth) in young adults. The combined strength of this correlation and limited individual variation anticipate that a non-invasive saliva test is able to forecast three statistically significant categories, equivalent to high, medium, and low cumulative caries experi ...

DESCRIPTION (provided by applicant): This grant will determine the efficacy of a humanized monoclonal antibody in treating a lethal Pseudomonas-induced lung injury. We have shown that the airspace instillation of a strain of Pseudomonas aeruginosa that contains the type Il system predictably causes lung necrosis, sepsis and death (J Clin Invest 1999). We have also shown th ...

DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease (COPD) affects 15-17 million people in the United States and is the fourth leading cause of death in the U.S. When COPD reaches end-stage, hypercarbia, not hypoxia, usually limits the COPD patients' ability to ambulate. Lung Volume Reduction Surgery remains investigational. Lung transplantation is available to only 900/yea ...

The acute respiratory distress syndrome (ARDS) is a severe, life-threatening disease process, which affects approximately 150,000 patients per year with an associated 30-50 percent mortality rate. Periluorocarbons are inert, colorless, low surface tension liquids that can carry large quantities of oxygen and carbon dioxide. Clinical studies are currently exploring the safety and effectiv ...

Metabolism of arichidonic acid by 12-lipoxygenase results in the formation of 12(s)-hydroxy eicosatetraenoic acid, which exhibits profound biological activity and plays an important role in tumor cell survival, angiogenesis, and metastases. Prostate cancer is the most commonly diagnosed neoplasm and second leading cause of male death in the United States. Human prostate cancer cells express incre ...

Description (provided by applicant): During systemic inflammatory response syndromes (SIRS), amplifying endogenous adenosine action by inhibiting adenosine deaminase (ADA) with 2-deoxycoformycin (pentostatin) reduces proinflammatory cytokine responses, limits tissue peroxidation, and has the potential to improve regional perfusion. Our long-term goal is to use pentostatin in the treatment of SIRS. ...

DESCRIPTION (provided by applicant): The proposed research will develop and optimize a discovery platform for new targets in the central nervous system (CNS). The developed platform, combining laser capture microdissection (LCM) with cDNA microarray analysis, will allow for the gene expression profiling of identified neuronal subtypes within the CNS. The discovery platform will provide for the dis ...

DESCRIPTION (provided by applicant): One widely considered approach to identify susceptibility alleles is through linkage disequilibrium (LD) between these alleles and a universal set of relatively frequent SNPs distributed in all or most ethnic populations. This approach, however, may be unrealistic when variant alleles responsible for disease susceptibility are infrequent or are specific to a pa ...