Award Data

In the setting of altitude-induced hypoxia, operator cognitive capacity degrades and can compromise both individual and team performance. This degradation is linked to falling brain energy (ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone bodies are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies have sho ...

Physically UnclonableFunctions (PUFs) have been proposed as central building blocks in cryptographic protocols and security architectures. PUFs are physical devices that exhibit a challenge/responsebehavior: when presented with a challenge, the device produces a response that is a random function of both the challenge and the physical properties of the device.In contrast to most digital designs, i ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Marburg virus (MARV) is a filamentous enveloped non-segmented negative sense RNA virus. This viruse is considered to be extremelydangerous with case fatality rates as high as 88-90%. Extensive efforts have gone towards effective vaccines for MARV prevention, however,none have been successfully established as licensed vaccines. Glycoprotein (GP) is the only surface protein of MARV. There are substa ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...

Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...

The objective of this Small Business Technology Transfer (STTR) project is to develop a prototype compact, portable electro-optic EM/thermal imaging system. The proposed electromagnetic/thermal imaging system can be directly utilized for thecharacterization of various RF structures including complex integrated circuits and large-scale antenna arrays. It provides near-field and thermal profiles of ...

Frontier Technology, Inc. (FTI) and University of Florida (UF) propose to validate and demonstrate designs for biomimetic camouflage systems (

A unique recombinant protein overexpression system will be investigated for the production of phosphotriesterase, an organophosphate hydrolase from Pseudomonas diminuta MG and Flavobacterium sp. ATCC 27551. This enzyme is a leading bioremediationcandidate for large-scale detoxification of insecticides and chemical warfare agents. The hydrolase will be prepared in three different versions using t ...