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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR/STTR Commercialization Assistance- Ease of use and deployment for a fast, scalable data movement infrastructure

    SBC: VISUS, LLC            Topic: 02b

    In recent decades, High Performance Computing (HPC) has risen as one of the key enablers of innovation in science and engineering. However, complexity and cost of deploying applications impedes industrial adoption. Problems include the quality, speed, and flexibility of software tools and the specialized expertise required to adapt solutions given the profusion of hardware configurations. Efficien ...

    STTR Phase II 2018 Department of Energy
  3. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: NIMH

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn

    SBC: MicroCures Inc.            Topic: NEI

    The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Pirenzepine for CIPN

    SBC: WinSanTor, Inc.            Topic: NCI

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathyCIPNis a debilitating condition that afflictsof cancer patients undergoing chemotherapy and limits the dose and duration of treatmentSymptoms range from sensory loss to painful neuropathy and are accompanied by electrophysiological and structural indices of nerve damageThe American Society of Clinical Oncology currently makes no recommendat ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. O-Glycan-dependent Immunotherapy for Cancer

    SBC: GlyTR Therapeutics, Inc.            Topic: 102

    Abstract For decadesthe treatment of cancer has relied on surgical resectionchemotherapy and or radiotherapyRecentlya number of immune based therapies have provided promising new approaches for cancer treatmentThe two most potent immunotherapies are monoclonal antibodymABbased bi specific proteinseg Bispecific T cell engagersBiTEand engineered Chimeric Antigen Receptor T cellsCAR TBoth act by indu ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Deriving Bone Density from Thoracic CT Scans, STTR Phase II

    SBC: BDI, Inc.            Topic: NIAMS

    ABSTRACT Osteoporosis is a major cause of disability and morbidity in our populationAs many asmillion Americans have osteoporosis andmillion more have osteopeniaHoweverbone mineral densityBMDassessment does not occur in many Americans when indicated and measure currently requires a separate referral and separate imaging scan to obtain BMDThe result is that onlyof Americans who are at risk of suffe ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. The Microscopic Imaging of Epigenetic Landscape- NeuroDevelopment (MIEL-ND) assay: a high throughput platform to screen compounds for neurodevelopmental effects

    SBC: VALA SCIENCES, INC.            Topic: 101

    Neurodevelopmental diseasesNDDsAutism Spectrum DisorderASDIntellectual DisabilitiesBipolar disordersand Schizophreniaetcare prevalent and due to errors in neurodifferentiation and neurocircuitryWhile NDDsin many casesare due to inherited mutationsevidence is mounting that prenatal exposure to environmental toxicants also cause NDDs via disruption of epigeneticse gmodifications of histoneshistone t ...

    STTR Phase I 2018 Department of Health and Human Services
  9. High Performance 3D Photonic Integration for Space Applications

    SBC: Freedom Photonics LLC            Topic: T8

    In this work, Freedom Photonics will team with University of California, Santa Barbara to develop a hybrid integration platform that integrates yielded, best-of-breed active optical components with low-cost, high functionality Silicon Photonics components in a manner that is compatible with foundry fabrication (such as AIM Photonics). This will be performed in a highly manufacturable manner, using ...

    STTR Phase II 2018 National Aeronautics and Space Administration
  10. Demonstration of Autonomous Differential Throttle-based Flight Control for Aircraft with Distributed Electric Propulsion

    SBC: Empirical Systems Aerospace, Inc.            Topic: T15

    A series of RDT&E activities is proposed to create and demonstrate a reconfigurable, autonomous flight controller for the Aircraft for Distributed Electric Propulsion Throttle-based Flight Control (ADEPT-FC) which was designed and built in Phase I, a 33 lb remote controlled aircraft featuring eight overwing electric ducted fans (EDFs) distributed spanwise along the wing’s trailing edge. The prop ...

    STTR Phase II 2018 National Aeronautics and Space Administration
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