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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. High Resolution Digital Imaging X-ray Detectors

    SBC: Aguila Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim is to develop a high resolution, high contrast detector for digital x-ray imaging systems. The target detector would have a Detective Quantum Efficiency much greater than 80%, a limiting resolution of at least 10 lp/mm, ultra-low noise, linear response and a dynamic range of more than 14 bits. The proposal is to build such a detector by using CdZnTe ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  2. MRI with Protease-Sensing Contrast Agents

    SBC: ALERION BIOMEDICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is to design, synthesize, and test a new class of biochemically activated magnetic resonance imaging (MRI) contrast agents to detect and monitor enzymatic activity in vivo. The proposal responds to the Program Announcement entitled "Systems and methods for small animal imaging". We base this work on the hypothesis that a ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  3. COMPUTER-AIDED TOOL FOR DIAGNOSTIC BREAST ULTRASOUND

    SBC: ALMEN LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Almen Laboratories has developed a sophisticated software system for imaging applications that provides extensive tools to identify objects and image features of interest, analyze the information content and then store, retrieve and compare different objects and images of interest based on this information. This proposal adapts the technology to the problem ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  4. Heterologous Production of Eleutherobin Precursors

    SBC: AMYRIS BIOTECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Terpenoids are a diverse class of natural compounds with equally diverse and potent bioactivities. Because the practical use of terpenoids hinges on the ability to extract or synthesize these compounds, only the most abundant or easily synthesized compounds have been commercially developed. The long-term goal of this Small Business Technology Transfer Phase I p ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  5. Convective Flow Tissue Assembly of Vascular Grafts

    SBC: APPLIED TISSUE AND MATERIALS, INC.            Topic: N/A

    Coronary heart disease accounts for the largest fraction of heart disease (the leading cause of death in the United States, affecting 12 million Americans) and has an annual cost to society that exceeds 110 billion dollars. There is a great clinical need for small diameter vascular artery grafts, as patients requiring multiple or repeat bypass procedures frequently lack adequate autogenous vessels ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  6. Small Animal Handling Devices for Multiplatform Imaging

    SBC: ASI INSTRUMENTS, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Small animal imaging initiatives are growing rapidly due to the enormous potential for improved understanding and treatment of human disease through animal imaging. At present, every radiologic modality available for use in humans has been adapted for small animal use. Other modalities have been devised solely for the purpose of in vivo imaging of research anim ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  7. A targeted peptide for PET imaging of cancer

    SBC: ATTENUON, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): ATN-161 (Ac-PHSCN-NH2) is a five amino acid peptide with potent anti-tumor, anti-angiogenic and anti-metastatic activity that specifically localizes to tumor cells and tumor endothelium. ATN-1 61 binds to several fully activated integrins which are involved in angiogenesis, metastasis and tumor growth and are present in both tumor and angiogenic endothelial ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  8. Novel lipid-based therapies for cystic fibrosis

    SBC: AVRION MOLECULAR, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Although the genetic cause of cystic fibrosis (CF), a lethal autosomal disorder, has been known for over a decade, an effective therapeutic method is still lacking. Pulmonary disease remains the major cause of morbidity and mortality in CF. The CF lung is marked by dysregulated inflammation and chronic infection, the end result being progressive bronchiectatic ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. New Topical Therapies for Psoriasis

    SBC: BETHESDA PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Psoriasis is a common, inflammatory disease of the skin characterized by hyperproliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. In the current studies, we will ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  10. Phenotyping All Genes of S. cerevisiae

    SBC: BIOLOG, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to further develop, miniaturize, and extend the new Phenotype MicroArray (PM) platform technology (1-3) and then utilize this improved technology to genomically analyze biological pathways and gene function in the model eucaryotic microorganism Saccharomyces cerevisiae. The steps will be 1) development of miniaturized, more eff ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
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