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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Non-Invasive Monitoring of Changes in Intracranial Pressure Due to Infections in the Central Nervous System

    SBC: Fenix Research Corporation            Topic: CBD192005

    Infections of the central nervous system (CNS) are associated with brain swelling and increased cerebral blood volume, as well as focal cerebral perfusion deficits, variable levels of cerebral blood flow and cerebral vasculitis. The net result is increased intracranial pressure (ICP) along with significant risk of brain tissue herniation and ischemic syndromes. ICP monitoring is critical in the ma ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  2. Development of a Non-invasive Negative Ophthalmodynamometer Capable of Measuring Intracranial Pressure in Humans

    SBC: Equinox Ophthalmic, Inc.            Topic: CBD192005

    Measurement of intracranial pressure (ICP) is essential in the diagnosis and management of numerous life threatening conditions. All current methods used clinically to measure ICP are invasive and require direct access to the cerebrospinal fluid giving them a significant side effect profile. The ability to measure ICP non-invasively would be a major milestone for patients. Spontaneous venous pulsa ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  3. Development of Small Molecule Therapeutics for Emerging Viral Agents

    SBC: Arisan Therapeutics, Inc.            Topic: CBD192006

    Arenaviruses comprise a diverse group of Old (Africa) and New World (Americas) species. Several species are associated with hemorrhagic fever (HF) with case-fatality rates as high as 30%. Arenaviruses infection typically occurs via the mucosal route through contact with excretions of an infected rodents although direct human-to-human transmission may occur in clinical settings. Lassa arenavirus en ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  4. Development of Small Molecule Therapeutics for Emerging Viral Agents

    SBC: Arisan Therapeutics, Inc.            Topic: CBD192006

    Ebolavirus species including Zaire (EBOV), Sudan (SUDV) and Bundibugyo (BDBV) are responsible for severe hemorrhagic fever outbreaks with high case fatalities in Africa. Weaponized pathogens present an additional threat to the health protection of the warfighter and first-generation prophylactic and therapeutic medical countermeasures (MCMs) may prove inadequate in biodefense settings. Ebolaviruse ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  5. Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)

    SBC: Technology Holding, LLC            Topic: CBD192007

    The threat of organophosphate (OP) chemical warfare agents (CWA) to United States military personnel is a persistent problem due to the relative ease of manufacturing chemical threats compared to nuclear and biological agents. Human butyrylcholinesterase (BChE) has been identified as a probable bio-scavenger of OP CWAs that could be used to protect individuals that could be exposed to OP CWAs. The ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  6. Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)

    SBC: ECHELON BIOSCIENCES, INC.            Topic: CBD192007

    Organophosphorus (OP) toxins and chemical warfare agents (CWA) are active nerve agents posing significant hazard for both soldiers and civilians. Butyrylcholinesterase (BChE) is a safe and effective bioscavenger that detoxifies OP and CWAs when injected either prophylactically or post-exposure; but a major technical problem has been producing a recombinant form of BChE with acceptable properties f ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  7. Nanoparticle-assisted Small Molecules as Broadly Active Antiviral Agents

    SBC: Luna Innovations Incorporated            Topic: CBD192006

    There is an increasing threat to warfighters from emerging viruses that have a high degree of pathogenicity and fatality. These highly infectious viruses are a great concern of being weaponized to endanger both civilian and warfighter health. The best weapon against potential infections by these viruses is vaccination. After exposure and infection, the most effective option of countermeasure is de ...

    SBIR Phase I 2020 Department of DefenseOffice for Chemical and Biological Defense
  8. Nanosatellite Payloads for Tactical Intelligence, Surveillance, and Reconnaissance

    SBC: Space Micro Inc.            Topic: SOCOM193001

    Space Micro will develop an innovative payload that can be hosted onboard a nanosatellite/ CubeSat bus, for the advancement of USSOCOM capabilities in rapid intelligence collection, surveillance, and reconnaissance (ISR). This R&D will improve and enhance capabilities in intelligence collection, surveillance, and reconnaissance from new spaceborne platforms.

    SBIR Phase I 2020 Department of DefenseSpecial Operations Command
  9. Nanosatellite Payloads for Tactical Intelligence, Surveillance, and Reconnaissance

    SBC: SA Photonics, Inc.            Topic: SOCOM193001

    CubeSats offer substantial reductions in operation and launch costs, while reducing time between request and employment of the capability. To address the USSOCOM needs, SA Photonics proposes an Infra-red Multispectral Imager for CubeSats (IMICS). IMICS collects diffraction-limited hyperspectral earth imagery, allowing identification of personnel, operating vessels / vehicles, structures and terrai ...

    SBIR Phase I 2020 Department of DefenseSpecial Operations Command
  10. Nanosatellite Payloads for Tactical Intelligence, Surveillance, and Reconnaissance

    SBC: Skeyeon, Inc.            Topic: SOCOM193001

    Skeyeon, Inc. has developed all technologies necessary to orbit an Earth Observation, EO, satellite at 250 km, developing a vehicle design; atomic oxygen resistant, low drag materials; high bandwidth, real-time RF links; electric propulsion for 3 year missions; and a 1 meter resolution optical telescope compressed into a 10 cm high framework. A constellation of 100’s-1,000’s of these vehicles ...

    SBIR Phase I 2020 Department of DefenseSpecial Operations Command
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