Award Data

DESCRIPTION (provided by applicant): Women face a variety of medical decisions during pregnancy and childbirth. While there are extensive educational resources for pregnant women, modern medicine presents decisions that many women are poorly equipped to make. Issues such as prenatal screening and mode of birth after a cesarean delivery require a significant degree of patient education to enable a ...

DESCRIPTION (provided by applicant): Reducing protein deposition events is essential for slowing the progression of Alzheimer's disease (AD), especially A 1-42 peptide oligomers that accumulate inside and outside neurons and cause functional compromise. Finding a strategy to reduce A oligomeric assemblies is widely thought to be the key objective for treating AD. Accumulation of A peptides is on ...

DESCRIPTION (provided by applicant): The objectives of this research project are to design and develop safe and efficient multifunctional delivery systems for systemic and target-specific delivery of small interfering RNA (siRNA) to treat human diseases with RNA interference (RNAi). RNAi is a natural mechanism for gene silencing and has a great potential to treat human disease by turning off speci ...

DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is of tremendous importance to the field of glycomics. In this application, we propose to develop a nove ...

DESCRIPTION (provided by applicant): A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions on various regulatory pathways. Currently, a statistical approach is universally used to identify the most relevant pathways in a given experiment. This approach only considers the set of genes present on each pathway ...

DESCRIPTION (provided by applicant): Multiple sclerosis (MS), a neurodegenerative disease that afflicts the central nervous system, is characterized by lesion formation and atrophy of the brain and spinal cord. Atrophy was reported to occur early in the disease and to increase with the disease progression in various cortical and sub-cortical regions, reflecting widespread loss of myelin, axons and ...

DESCRIPTION (provided by applicant): The cryptophycins are a structurally diverse class of polyketide/non-ribosomal peptide natural products that possess potent anticancer activity. However, despite this impressive activity, the development of the cryptophycins into a beneficial cancer chemotherapeutic agent has suffered from clinically significant neurotoxicity that correlates with treatment. Non ...

DESCRIPTION (provided by applicant): The overall objective of our proposed research is to discover a PPARg-free thiazolidinedione (TZD) which shows antidiabetic activity in a rodent model of Type 2 diabetes and demonstrates the necessary drug-like qualities to become a clinical candidate for human therapeutics. The insulin sensitizing agents of the TZD class are conventionally thought to operate t ...

DESCRIPTION (provided by applicant): The overall objective of the proposed research is to discover a PPAR?-sparing thiazolidinedione (TZD) which displays efficacy in a rodent model of non-alcoholic fatty liver disease (NAFLD) and demonstrates the necessary drug-like qualities to become a potential clinical candidate for human therapeutics. The TZD class of insulin sensitizing agents are convention ...

DESCRIPTION (provided by applicant): Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC. While they are capable of supplying oxygen to the tissue, their side effects appear to be one of the most serious and difficult to solve problems, and a novel programmatic approach ...