Award Data

DESCRIPTION provided by applicant Stress urinary incontinence SUI in women is an increase of pelvic floor compliance which results in decrease of urethral pressure typically through childbirth and presents as urine leakage during exertion SUI has significant impact on womenandapos s health including an association with increased levels of depression Curative options are limited to the in ...

DESCRIPTION provided by applicant Extending liquid chromatographic column technology to even higher performance levels has given rise to ultra high pressure liquid chromatography UPLC core shell particle technology and instrumental developments such as lower volumes for injector and detector hydraulics In spite of these advances there is still room for improvement in speed selectivity and ...

DESCRIPTION provided by applicant This proposed Phase II project will lead to a commercial product capable of transfecting individual target cells This new biotool uses a patented microfabricated chip called a nanofountain probe NFP to deliver molecules into live individual target cells by single cell electroporation which induces temporary nanopores in the cell membrane via the applicat ...

DESCRIPTION provided by applicant PhotoniCare Inc is a medical device company developing a handheld biophotonics imaging system suitable for use by otolaryngologists ear nose and throat specialists ENT and primary care physicians PCP to enable real time D assessment of sub surface tissue structure in the middle ear Significance ENTs and PCPs have limited tools with which to diagn ...

DESCRIPTION provided by applicant Fucosylation plays an important role in many cellular processes Fucosylated oligosaccharides in the cell are involved in many biochemical recognition processes microbial infections toxin entry and cancer cell metastasis These properties make fucosylated molecules valuable for pharmaceutical and drug discovery needs but current production methods are very ...

The goal of this project is to develop, prototype, and experimentally validate a new Differential Global Navigation Satellite System (DGNSS) capable of providing sub-centimeter positioning accuracy for quasi-static scientific, survey, and structural health monitoring application. The main feature of the proposed DGNSS solution is that it leverages publically available GNSS reference data from exis ...

DESCRIPTION provided by applicant Diabetes represents a global health crisis In the United States alone approximately million people of the population suffer from diabetes resulting in direct medical costs of $ billion National Diabetes Statistics Report New medicines that can restore cell function in these patients thereby preventing or alleviating the debilitatin ...

During Phase 1 of the project, Sharma & Associates, Inc. developed a concept for high speed freight truck intended for 70-ton, regular freight and bi-modal operation, at speeds up to 150 mph. The truck uses a rigid frame and an indpendent, compliant, primary suspension for its basic architecture. Constant contact side-bearings and yaw dampers were also added to improve dynamic performance. Vehi ...

It is estimated that 220,000 people suffer cardiac arrest each year in the US, of whom only 10,000 survive to hospital discharge. The number of survivors could increase 10-fold if paramedical attention and/or defibrillation were available within a few min

DESCRIPTION (provided by applicant): The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically normal mucosa. Missed lesions on colonoscopy are a major problem (conservatively estimated to be ~25% of adenomas and ~4-5% of carcinomas) w ...