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DESCRIPTION provided by applicant Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticated mass spectrometry Hydrophilic interaction liquid chromatography HILIC has great use in separations of glycopeptides and released glycans exhibitin ...

In the proposed effort, we will leverage this extensive experience and capabilities to realize a frequency agile mmW radiometer that can cover the range of DC-110 GHz and can be scaled to DC-200 GHz under Phase II. Ours is a photonic system that multiplies and up-coverts a low-frequency reference signal onto an optical carrier (laser) using EO modulation, then uses the modulation sidebands to inj ...

Training in the symptoms of Spatial Disorientation (SD) has shown to be valuable in aiding pilots to recognize its onset and provide a means for mitigating its effects, but such demonstrations have traditionally been associated with specialized equipment and devices. Since the vast majority of pilots for the commercial aviation jet fleet are trained (or recertified) on 6-degree-of-freedom (DOF) h ...

THE ROLLER PUMP, USED TO PUMP BLOOD FLOW DURING CARDIOPULMONARY BYPASS AND TO PROVIDE LONG-TERM CIRCULATORY SUPPORT, IS A CONSTANT-BLOOD-FLOW DEVICE. IT MAINTAINS CONSTANT FLOW INDEPENTLY OF THE CLINICALLY EXPECTED CHANGES IN INLET PRESSURES. A DECREASE IN BLOOD SUPPLY TO THE INLET OF THE PUMP WITHOUT A CONCOMITANT DECREASE IN PUMP SPEED CAN CAUSE EXCESSIVE SUCTION LEADING TO AIR EMBOLISM, THROMBO ...

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CYTOMEGALOVIRUS (CMV), A MEMBER OF THE HERPES VIRUS GROUP, IS PRESENT IN THE BLOOD OF A LARGE PORTION OF THE HUMAN POPULATION. ADMINISTRATION OF THIS BLOOD TO HIGH-RISK PATIENTS MAY RESULT IN DEATH. ENZO PROPOSES THE DEVELOPMENTOF A QUICK, SPECIFIC, EASY AND ECONOMICAL DIAGNOSTIC TEST, BASED ON NONRADIOACTIVE DNA-DNA HYBRIDIZATION, TO DIRECTLY SCREEN HUMAN BLOOD FOR CMV. PHASE I DEVELOPMENT WILL B ...

ENZON, INC. IS INVOLVED IN THE DEVELOPMENT OF THERAPEUTIC ENZYMES FOR HUMAN AND VETERINARY USE. MANY ENZYMES HAVE SHOWN EFFECTIVENESS AS ANTICANCER AGENTS ON INITIAL INJECTION, BUT THEIR IMMUNOGENICITY AND SHORT PLASMA HALF-LIFE HAVE PREVENTED EXPLOITATION OF THEIR POTENTIAL. ENZON, INC. WILL MODIFY TWO GLUTAMINASE-ASPARAGINASES AND A HISTIDASE USING A PATENTED COMPANY PROCESS TO PRODUCE ENZYME-PO ...

THE FEASIBILITY OF BUILDING A PERSONAL COMPUTER MODEL OF THEEVACUATION PROCESS WILL BE STUDIED, USING AN EXPERIMENTAL MODEL DEVELOPED BY GOURARY ASSOCIATES INC. THE RESULTING MODEL WILL PERMIT THE STUDY AND VISUALIZATION OF PASSENGER MOVEMENTS DURING EVACUATION. IT WILL ALSO ALLOW THE STUDY OF THE EFFECTS OF CROWDING, FIRE, OBSTRUCTIONS, AND OTHER EFFECTS DURING THE EVACUATION PROCESS. THE MODEL W ...

THE PRIMARY OBJECTIVE OF THE PROJECT IS TO DEVELOP AN IMMUNOSORBENT DEVICE FOR REMOVAL OF EXCESS PARATHYROID HORMONE (PTH) FROM THE BLOOD OF CHRONIC RENAL-FAILURE PATIENTS. THE PROJECT WILL INVOLVE SYNTHESIS OF A SPECIFIC IMMUNOSORBENT DESIGN OF A HEMOPERFUSION CARTRIDGE AND ANIMALTESTING TO ASSESS DEVICE EFFICACY. A SUCCESSFUL OUTCOME IN PHASE I WILL LEAD TO THE EVALUATION OF THE DEVICE IN HUMAN ...