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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's disease

    SBC: NEURODON, LLC            Topic: NIA

    In this Phase IIB SBIR project for Alzheimer’s disease (AD) drug development, Neurodon LLC proposes to conduct preclinical development and IND-enabling activities on our novel, orally available lead and backup compounds that, in our preceding Phase II project, showed neuroprotection and beneficial effects on learning and memory in a transgenic model of AD. Despite the enormity of AD as a nationa ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies

    SBC: VITAN-BIOTECH LLC            Topic: 300

    Project SummaryA broad range of neurological indications, including schizophrenia, pain, Parkinson's and Alzheimer's diseases, and autism have been linked to G-protein coupled receptor proteins (GPCRs), making them attractive targets for therapy. Understanding GPCR dysfunction is essential for effective therapeutic development. However, deciphering the functions of GPCRs remains a daunting task in ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Fluoroscopic drill attachment for orthopedic trauma surgery

    SBC: ECLIPSE ORTHOPAEDICS, LLC            Topic: NIAMS

    Abstract For about 175,000 leg and hip fractures each year, the best treatment is for an orthopaedic surgeon to implant a stiff metal rod, or intramedullary (IM) nail, through the center of the bone and fix the nail to the bone with screws (distal locking). Distal locking can be difficult and time-consuming step and presents two major challenges. First, the procedure uses C-arm fluoroscopy for gui ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients

    SBC: Allander Biotechnologies            Topic: NIDCR

    Summary Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy (RT or CRT) and a limiting factor to using the optimal dose of radiation for effective cancer treatment. Intensity modulated RT (IMRT) and stereotactic Body RT (SBRT) spare more normal tissues and lessen chronic side effects, but not oral mucosa in head and neck cancer patients. To date, Pali ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Advanced Pediatric Airway Trainer for Enhanced Clinical Education in Pediatric Critical Care

    SBC: TDA RESEARCH, INC.            Topic: NICHD

    Project Summary/Abstract Clinical training aids such as surgical mannequins and procedural trainers are important tools for teaching proper technique to physicians and first responders. However, the majority of these training tools were developed for adult anatomies. Pediatric patients are often more challenging to treat, but few resources exist for advanced simulation in pediatric critical care e ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Amino Acids and Pediatric Hepatic Steatosis

    SBC: THE AMINO COMPANY LLC            Topic: 300

    7. Project Summary/Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in North America (1). Hepatic steatosis (HS) is the hallmark of NAFLD (2). NAFLD may transition in sub-groups to chronic inflammation (non- alcoholic steatohepatitis, NASH), and ultimately to cirrhosis. HS is prevalent in all stages of NAFLD. 3-10% of all children in the US and 40-70% of obese ch ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. The Point Powered: A Robust Actuated Prosthetic Finger for Partial Hand Amputation

    SBC: POINT DESIGNS, LLC            Topic: NIBIB

    ABSTRACT Approximately 600,000 people live with partial hand limb loss (PHLL) in the United States, with an estimated 14,500 new cases occurring each year. Despite the advances in miniaturized electronics and motors, there has been very little advancement in mechatronic prosthetic digits for this underserved patient population. In fact, to date, there is only one myoelectric prosthetic option for ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Optical gearbox enabled high-speed multiphoton microscope

    SBC: PHOTOMATRIX            Topic: 101

    ABSTRACT Neurological disorders affect millions of people each year, many with no cures. Researchers and clinicians are actively seeking a deeper understanding of how the human brain functions to develop new treatments and cures. Optical functional imaging is a tool broadly applied in neuroscience. The advance of genetically encoded functional indicators allows the visualization of neuronal activi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Targeting inflammation and oxidative stress to treat acute lung injury with CNP-miR146a

    SBC: CERIA THERAPEUTICS INC            Topic: NHLBI

    SUMMARYAcute respiratory distress syndrome (ARDS) accounts for 10% of ICU admissions worldwide, with a mortality as high as 46%. ARDS incidence has risen dramatically during the COVID-19 pandemic. Despite improvements in critical care and early detection of lung injury, the management of ARDS remains largely supportive. Although mechanical ventilation may provide the necessary life support, impair ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. A ratcheting pediatric prosthetic finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    A ratcheting pediatric prosthetic finger using advancedrapid manufacturing technology ABSTRACT The goal of the proposed project is to develop and commercialize a purely mechanical, ratcheting pediatric prosthetic finger – the Point Mini – which 1) has an industry leading strength to weight ratio, 2) can be operated unilaterally (one-handed), 3) offers anatomical rotation and flexion around the ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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