Award Data

N/A

The proposed research is aimed at developing a new molecular recognition technology for drug discovery. Stable liposome-based biosensors, called Biosomes TM, turn from blue to red in response to a specific molecular recognition event. The Biosomes can be functionalized with a specific receptor ligand or enzyme substrate so that they respond specifically to a particular receptor or enzyme. Our aim ...

N/A

N/A

"Creatv MicroTech proposes to develop high precision x-ray anti-scatter grids for medical imaging to improve image contrast of diseased tissue by reducing the detection of scattered x-rays produced by the imaging object. Some of the potential properties of the proposed anti-scatter grid are: (i) the grid pattern is two-dimensional, (ii) the vertical air-core opening is focused to a point x-ray sou ...

Growth hormone (GH) is a pituitary derived protein that stimulates somatic growth and other anabolic processes. Recombinant human OH is used to stimulate linear growth in children and to treat cachexia in AIDS patients. The protein must be injected daily for maximum effectiveness. We propose to create modified OH proteins that are equal or superior to natural OH in stimulating anabolic processes i ...

This project is designed to develop new agents with dual anti-angiogenic and cytotoxic properties for the chemoprevention and treatment of human lung cancers. Our strategy is to simultaneously attack the endothelial cells of the tumor vascular bed and the tumor cells using a series of novel peptide antagonist monomers and dimers with anti-angiogenic and cytotoxic effects. Recently we found that "t ...

N/A

Disinfection is a critical process step in potable water treatment. Chlorine is currently the most widely used, and least costly disinfectant. An unfortunate by-product of chlorine disinfection is the formation of carcinogenic trihalomethanes (THMs) when chlorine reacts with organics dissolved in water. A further disadvantage of chlorine is its inability to remove viruses. Ozone is a more powerful ...

Osteoporosis is a major worldwide public health problem with over 20 million individuals affected in the united states. Over 1.5 million fractures occur in the united states annually, resulting in 750,000 visits to the physician and long term hospitalization with a total impact to the health care system in excess of billion dollars. The current state-of-the-art in clinical diagnosis for Osteoporo ...